BGC0000950 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000950 (Streptomyces sp. DSM 5940)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like	1	35,298	napsamycin A/napsamycin B/napsamycin C/napsamycin D/mureidomycin A/mureidomycin B	NRPS:Type I+other:nucleoside	100%

BGC0000950 - Region 1 - NRPS-like

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Location: 1 - 35,298 nt. (total: 35,298 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 35,299
Label		BGC0000950

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000950	1.83	NRP, Other (Nucleoside)	napsamycin A, napsamycin B, napsamycin C, napsamycin D, mureidomycin A, mureidomycin B	Streptomyces sp. DSM 5940
BGC0001925	0.67	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0000343	0.64	NRP	enterobactin	Pseudomonas sp. J465
BGC0000900	0.63	Other	ferrichrome	Aspergillus oryzae
BGC0002710	0.62	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000348	0.57	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000921	0.56	Other (Shikimate-derived), Polyketide, NRP	promysalin	Pseudomonas putida
BGC0000327	0.54	NRP	netropsin	Streptomyces ambofaciens ATCC 23877
BGC0000979	0.53	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980	0.53	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000950	1.00	NRP, Other (Nucleoside)	napsamycin A, napsamycin B, napsamycin C, napsamycin D, mureidomycin A, mureidomycin B	Streptomyces sp. DSM 5940
BGC0000375	0.67	NRP	indigoidine	Streptomyces chromofuscus
BGC0001925	0.67	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0002710	0.66	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0001249	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0000348	0.63	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000876	0.63	Other	neopolyoxin C	Streptomyces tendae
BGC0000921	0.62	Other (Shikimate-derived), Polyketide, NRP	promysalin	Pseudomonas putida
BGC0000327	0.61	NRP	netropsin	Streptomyces ambofaciens ATCC 23877

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 33350:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 28485:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

npsP3

AMP-binding (283..679): X

nrpys: mTyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DPGIYGLLAK
Nearest Stachelhaus code(s):: mTyr DPGIYGLLAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

npsP5

AMP-binding (30..426): X

nrpys: L-Dbu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DIWQGTADDK
Nearest Stachelhaus code(s):: L-Dbu DIWQGTADDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

npsP6

AMP-binding (16..412): X

nrpys: Htia

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DPHHFGLIGK
Nearest Stachelhaus code(s):: Htia DPHHFGLIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

npsP8

Search NORINE for peptide: strict or relaxed

AMP-binding (19..420): Met

nrpys: Met

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGLILGICVK
Nearest Stachelhaus code(s):: Met DGLILGICVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)