BGC0000951 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000951 (Streptomyces coeruleorubidus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like,NRPS	1	30,311	pacidamycin 1/pacidamycin 2/pacidamycin 3/pacidamycin 4/pacidamycin 5/pacidamycin 6/pacidamycin 7/pacidamycin D	NRPS:Type I	100%

BGC0000951 - Region 1 - NRPS,NRPS-like

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Location: 1 - 30,311 nt. (total: 30,311 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 30,312
Label		BGC0000951

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000951	2.00	NRP	pacidamycin 1, pacidamycin 2, pacidamycin 3, pacidamycin 4, pacidamycin 5, pacidamycin 6, pacidamycin 7, pacidamycin D	Streptomyces coeruleorubidus
BGC0002295	0.68	NRP, Saccharide	minimycin	Streptomyces hygroscopicus
BGC0000375	0.67	NRP	indigoidine	Streptomyces chromofuscus
BGC0001925	0.67	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0001249	0.64	NRP	dimethylcoprogen	Alternaria alternata
BGC0002710	0.64	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000900	0.63	Other	ferrichrome	Aspergillus oryzae
BGC0000876	0.59	Other	neopolyoxin C	Streptomyces tendae
BGC0000921	0.58	Other (Shikimate-derived), Polyketide, NRP	promysalin	Pseudomonas putida
BGC0000348	0.58	NRP	ergovaline	Epichloe festucae var. lolii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000951	1.00	NRP	pacidamycin 1, pacidamycin 2, pacidamycin 3, pacidamycin 4, pacidamycin 5, pacidamycin 6, pacidamycin 7, pacidamycin D	Streptomyces coeruleorubidus
BGC0002295	0.67	NRP, Saccharide	minimycin	Streptomyces hygroscopicus
BGC0000375	0.67	NRP	indigoidine	Streptomyces chromofuscus
BGC0001925	0.67	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0001249	0.66	NRP	dimethylcoprogen	Alternaria alternata
BGC0002710	0.65	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000900	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0000876	0.63	Other	neopolyoxin C	Streptomyces tendae
BGC0000921	0.63	Other (Shikimate-derived), Polyketide, NRP	promysalin	Pseudomonas putida
BGC0000348	0.62	NRP	ergovaline	Epichloe festucae var. lolii

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 30311:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

pacL

AMP-binding (278..677): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DPGIYGQLAK
Nearest Stachelhaus code(s):: mTyr DPGIYGLLAK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

pacO

AMP-binding (23..425): X

nrpys: Gly, Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLSSVGVCYK
Nearest Stachelhaus code(s):: Ala DVFSVAVVYK (65% 8Å match); cycHexAla DLLSVGGVFK (59% 8Å match)
Stachelhaus code match:: 60% (weak)

pacP

AMP-binding (30..426): X

nrpys: L-Dbu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DIWQGTADDK
Nearest Stachelhaus code(s):: L-Dbu DIWQGTADDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

pacU

Search NORINE for peptide: strict or relaxed

AMP-binding (13..412): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DCHYFALITK
Nearest Stachelhaus code(s):: bMe-Asp DCFFFALITK (76% 8Å match); Ala DCFFFALITK (68% 8Å match)
Stachelhaus code match:: 80% (moderate)