Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000952.1:
Cluster 1NRP / Polyketide166339
The following clusters are from record BGC0000952.2:
Cluster 2NRP / Polyketide120262
The following clusters are from record BGC0000952.3:
Cluster 3NRP / Polyketide1121769

BGC0000952, pristinamycin biosynthetic gene cluster from Streptomyces pristinaespiralis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: pristinamycin
PubChem ID: 24847675
SMILES string: Copy to clipboard
Molecular formula: C71H84N10O17
Average molecular mass: 1349.506 Da
Molecular activity: Antibacterial
Molecular target: 50 S ribosome

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Cyclic depsipeptide (cyclic)
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I / Trans-AT type I
Starter unit:
Isobutyryl-CoA
CBW45739
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Gene cluster description

pristinamycin (BGC0000952). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank FR681999. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Dr. Yvonne Mast (University Tuebingen, IMIT)

Literature references

1. Mast Y et al. (2011) Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis. Microb Biotechnol 4(2):192-206. doi: 10.1111/j.1751-7915.2010.00213.x.

BGC0000952, pristinamycin biosynthetic gene cluster from Streptomyces pristinaespiralis. Locus 2. Full MIBiG entry.

Chemical compounds

Compound: pristinamycin
PubChem ID: 24847675
SMILES string: Copy to clipboard
Molecular formula: C71H84N10O17
Average molecular mass: 1349.506 Da
Molecular activity: Antibacterial
Molecular target: 50 S ribosome

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Cyclic depsipeptide (cyclic)
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I / Trans-AT type I
Starter unit:
Isobutyryl-CoA
CBW45739
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Gene cluster description

pristinamycin (BGC0000952). Gene Cluster 2. Biosynthetic class = NRP/Polyketide. GenBank FR682000. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Dr. Yvonne Mast (University Tuebingen, IMIT)

Literature references

1. Mast Y et al. (2011) Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis. Microb Biotechnol 4(2):192-206. doi: 10.1111/j.1751-7915.2010.00213.x.

BGC0000952, pristinamycin biosynthetic gene cluster from Streptomyces pristinaespiralis. Locus 3. Full MIBiG entry.

Chemical compounds

Compound: pristinamycin
PubChem ID: 24847675
SMILES string: Copy to clipboard
Molecular formula: C71H84N10O17
Average molecular mass: 1349.506 Da
Molecular activity: Antibacterial
Molecular target: 50 S ribosome

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Cyclic depsipeptide (cyclic)
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I / Trans-AT type I
Starter unit:
Isobutyryl-CoA
CBW45739
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Gene cluster description

pristinamycin (BGC0000952). Gene Cluster 3. Biosynthetic class = NRP/Polyketide. GenBank FR682001. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Dr. Yvonne Mast (University Tuebingen, IMIT)

Literature references

1. Mast Y et al. (2011) Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis. Microb Biotechnol 4(2):192-206. doi: 10.1111/j.1751-7915.2010.00213.x.