BGC0000953 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000953 (Streptomyces vinaceusdrappus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like	1	37,337	amicetin	saccharide:aminoglycoside	100%

BGC0000953 - Region 1 - NRPS-like

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Location: 1 - 37,337 nt. (total: 37,337 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 37,338
Label		BGC0000953

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000953	0.94	Saccharide	amicetin	Streptomyces vinaceusdrappus
BGC0002652	0.62	Other, Saccharide	cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E	Streptomyces sp. SHP22-7
BGC0000278	0.46	Polyketide	urdamycin	Streptomyces fradiae
BGC0000772	0.31	Saccharide	lipopolysaccharide	Brucella melitensis
BGC0001137	0.29	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000900	0.28	Other	ferrichrome	Aspergillus oryzae
BGC0001561	0.27	NRP	curacomycin	Streptomyces curacoi
BGC0000882	0.26	Other	mildiomycin	Streptomyces rimofaciens
BGC0000813	0.26	Alkaloid	K-252a	Nonomuraea longicatena
BGC0001379	0.26	NRP	BD-12	Streptomyces luteocolor

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000953	1.00	Saccharide	amicetin	Streptomyces vinaceusdrappus
BGC0002652	0.85	Other, Saccharide	cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E	Streptomyces sp. SHP22-7
BGC0000278	0.76	Polyketide	urdamycin	Streptomyces fradiae
BGC0000772	0.64	Saccharide	lipopolysaccharide	Brucella melitensis
BGC0001137	0.62	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000900	0.62	Other	ferrichrome	Aspergillus oryzae
BGC0001561	0.60	NRP	curacomycin	Streptomyces curacoi
BGC0001379	0.60	NRP	BD-12	Streptomyces luteocolor
BGC0000882	0.60	Other	mildiomycin	Streptomyces rimofaciens
BGC0000813	0.60	Alkaloid	K-252a	Nonomuraea longicatena

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 11328 - 37337:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

amiL

AMP-binding (16..392): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TGNFVAQNAK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

amiR

PKS_AT (81..238): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

amiT

AMP-binding (233..638): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DMYNMGLIHK
Nearest Stachelhaus code(s):: Lys DMYNFGLIHK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)