BGC0000955: althiomycin biosynthetic gene cluster from Myxococcus xanthus
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Location: 1 - 33,020 nt. (total: 33,020 nt).
This entry is originally from NCBI GenBank FR831800.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000955
Short description althiomycin biosynthetic gene cluster from Myxococcus xanthus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
FR831800.1
via Knock-out studies, Heterologous expression
Compounds
  • althiomycin
Species Myxococcus xanthus [taxonomy]
References
Chemical products information
althiomycin Evidence:
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C16H17N5O6S2
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCA29199.1
  • almE
 730 - 2067 (+) drug resistance transporter
  • Transport
  • Other in vivo study
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  • CCA29200.1
  • almD
 2191 - 3186 (+) N-oxygenase
  • Tailoring
  • Knock-out
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  • CCA29201.1
  • almC
 3216 - 4121 (+) SAM-dependent methyltransferase
  • Tailoring
  • Knock-out
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  • CCA29202.1
  • almA
 4229 - 11416 (+) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
  • Knock-out
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  • CCA29203.1
  • almB
 11416 - 27699 (+) non-ribosomal peptide synthetase/polyketide synthase
  • Scaffold biosynthesis
  • Knock-out
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  • CCA29204.1
  • almF
 27699 - 28664 (+) putative type-II thioesterase
  • Activation / processing
  • Knock-out
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Biosynthesis information

Biosynthetic modules

Name
0
Type
nrps-type1
Genes
almA
Substrates
glycine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (Starter), adenylation
Name
1
Type
nrps-type1
Genes
almA
Substrates
cysteine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (Heterocyclization), adenylation, oxidase
Name
2
Type
nrps-type1
Genes
almB
Substrates
serine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (LCL), adenylation, epimerase
Name
3
Type
nrps-type1
Genes
almB
Substrates
cysteine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (Heterocyclization), adenylation, epimerase, oxidase
Name
4
Type
nrps-type1
Genes
almB
Substrates
glycine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (DCL), adenylation
Name
5
Type
pks-modular
Genes
almB
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
Annotation changelog

Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
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Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Corrected NRP module activity
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2022-09-15
Removed ketoreductase stereochemistry annotation from modules without ketoreductases
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2022-09-15
Changed amino acid substrates to lower case
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Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
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2019-10-16
Updated compound(s) information (NPAtlas curation)
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Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
  • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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