Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000955.1:
Cluster 1NRP / Polyketide133020

BGC0000955, althiomycin biosynthetic gene cluster from Myxococcus xanthus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Althiomycin
ChemSpider ID: 4576669
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Antibacterial
Molecular target: ribosome

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
almA (CCA29202.1)
Module 0
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: Starter
Module 1
A specificity: Cysteine
Evidence for specificity: Structure-based inference
C domain subtype: Heterocyclization
Scaffold-modifying domain: Oxidation
almB (CCA29203.1)
Module 2
A specificity: Serine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: LCL
Module 3
A specificity: Cysteine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Heterocyclization
Scaffold-modifying domain: Oxidation
Module 4
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: DCL
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Other
Thioesterase type:
None
Release / cyclization type:
Other

Modular polyketide synthases:
almB (CCA29203.1)
Module 5
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference

Gene cluster description

althiomycin (BGC0000955). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank FR831800, positions 1-33020. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Daniel Krug (Helmholtz Institute for Pharmaceutical Research Saarland)

Literature references

1. Cortina NS et al. (2011) Identification and characterization of the althiomycin biosynthetic gene cluster in Myxococcus xanthus DK897. Chembiochem 12(9):1411-6. doi: 10.1002/cbic.201100154. Epub 2011 May
2. Fujimoto H et al. (1970) Studies on the mode of action of althiomycin. J Antibiot (Tokyo) 23(6):271-5.
3. Kunze B et al. (1982) Isolation and identification of althiomycin from Cystobacter fuscus (myxobacterales). J Antibiot (Tokyo) 35(5):635-6.