BGC0000958: antimycin biosynthetic gene cluster from Streptomyces sp. S4
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Location: 81,953 - 106,578 nt. (total: 24,626 nt).
This entry is originally from NCBI GenBank NZ_FR873698.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000958
Short description antimycin biosynthetic gene cluster from Streptomyces sp. S4
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide (Other)
Loci NCBI GenBank: NZ_FR873698.1
Compounds
  • antimycin
Species Streptomyces sp. S4 [taxonomy]
References
Chemical products information
antimycin [synonyms: antipiricullin, fintrol, virosin]
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C28H40N2O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • STREPS4_RS11215
  • WP_003946493.1
 81953 - 82474 (-) RNA polymerase sigma factor
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  • STREPS4_RS11220
  • WP_026048085.1
 82523 - 83833 (-) condensation domain-containing protein
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  • STREPS4_RS11225
  • WP_010639240.1
 84401 - 93094 (+) non-ribosomal peptide synthetase
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  • STREPS4_RS11230
  • WP_010639241.1
 93087 - 96908 (+) type I polyketide synthase
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  • STREPS4_RS11235
  • WP_010639242.1
 96958 - 98184 (+) crotonyl-CoA carboxylase/reductase
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  • STREPS4_RS11240
  • WP_010639243.1
 98273 - 99751 (-) AMP-binding protein
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  • STREPS4_RS11245
  • WP_003946500.1
 99751 - 100008 (-) acyl carrier protein
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  • STREPS4_RS11250
  • WP_010639244.1
 100306 - 101361 (+) 1,2-phenylacetyl-CoA epoxidase subunit A
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  • STREPS4_RS11255
  • WP_003946502.1
 101358 - 101660 (+) 1,2-phenylacetyl-CoA epoxidase subunit B
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  • STREPS4_RS11260
  • WP_010639245.1
 101653 - 102441 (+) phenylacetate-CoA oxygenase subunit PaaC
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  • STREPS4_RS11265
  • WP_003946504.1
 102438 - 102956 (+) phenylacetate-CoA oxygenase subunit PaaJ
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  • STREPS4_RS11270
  • WP_010639247.1
 102968 - 104071 (+) 2Fe-2S iron-sulfur cluster-binding protein
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  • STREPS4_RS11275
  • WP_010639249.1
 104118 - 104894 (+) SDR family oxidoreductase
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  • STREPS4_RS11280
  • WP_003946507.1
 104940 - 105788 (+) tryptophan 2,3-dioxygenase family protein
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  • STREPS4_RS11285
  • WP_010639251.1
 105778 - 106578 (+) alpha/beta fold hydrolase
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Polyketide-specific information
Subclass Other
Cyclic? yes
Release type
  • Macrolactamization
Polyketide-synthases
Genes Properties Modules
STREPS4_RS11230 Synthase subclass: Modular type I
Module 3
Specificity: Various atypical acyl-CoAs
Evidence for specificity: Activity assay
Genes: STREPS4_RS11230
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP), Thioesterase
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactonization
NRP-synthases
Gene Modules
STREPS4_RS11225
Module 1
Specificity: threonine
Evidence for specificity:
  • Activity assay
Condensation domain type: Starter
Module 2
Specificity: pyruvic acid
Evidence for specificity:
  • Activity assay
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: ROMZZBLG2S6RXTJZIS4SPKBK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed subcluster from chem_moiety
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Reworked NRPS/PKS modules to match reference papers
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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