BGC0000959: aspyridone A biosynthetic gene cluster from Aspergillus nidulans FGSC A4
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Location: 383,588 - 417,319 nt. (total: 33,732 nt).
This entry is originally from NCBI GenBank BN001305.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000959
Short description aspyridone A biosynthetic gene cluster from Aspergillus nidulans FGSC A4
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
BN001305.1
383588 - 417319
via Enzymatic assays, Heterologous expression
Compounds
  • aspyridone A
  • aspyridone B
Species Aspergillus nidulans FGSC A4 [taxonomy]
References
Chemical products information
aspyridone A Evidence:
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C19H23N1O4
Chemical database entries
PubCHEM
aspyridone B Evidence:
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C19H23N1O5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ANIA_08408
  • CBF80479.1
 383588 - 385551 (-) Cytochrome P450 monooxygenase (Eurofung)
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    • ANIA_08409
    • CBF80481.1
    		 385918 - 387078 (+) enoylreductase
    • Scaffold biosynthesis
    • Heterologous expression Activity assay
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    • ANIA_08410
    • CBF80483.1
    		 387281 - 389445 (+) FAD-dependent monooxygenase (Eurofung)
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      • ANIA_08411
      • CBF80485.1
      		 390561 - 392240 (-) PKS-NRPS hybrid
      • Scaffold biosynthesis
      • Heterologous expression Other in vivo study Activity assay
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      • ANIA_08412
      • CBF80487.1
      		 392716 - 404651 (+) hybrid PKS-NRPS (Eurofung)
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        • ANIA_08413
        • CBF80489.1
        		 404935 - 407139 (-) Exporter (Eurofung)
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          • ANIA_08414
          • CBF80491.1
          		 407965 - 410253 (+) Putative Zn(II)2Cys6 transcription factor (Eurofung)
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            • ANIA_11608
            • CBF80493.1
            		 412393 - 412551 (-) hypothetical protein
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              • ANIA_08415
              • CBF80495.1
              		 415926 - 417319 (+) Acyl-CoA dehydrogenase (Eurofung)
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                Biosynthesis information

                Biosynthetic modules

                Name
                1
                Type
                nrps-type1
                Genes
                ANIA_08412
                Substrates
                tyrosine, phenylalanine, tryptophan, 4-fluorophenylalanine (evidence: Activity assay)
                Integrated Monomers
                Domains
                condensation, adenylation
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Add new compound: aspyridone B
                • (ID: H5KVDLSVQ3TJW7SKCDNBDEVC)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Corrected NRP module activity
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Corrected NRP gene names
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: ZUAEFEJPIFGA5SNZGJWBG3IU)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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