Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000959.1:
Cluster 1NRP / Polyketide133732

BGC0000959, aspyridone biosynthetic gene cluster from Aspergillus nidulans. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: aspyridone A
PubChem ID: 54710080
SMILES string: Copy to clipboard
Molecular formula: C19H23NO4
Average molecular mass: 329.396 Da
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Unknown

Nonribosomal peptide synthetases:
ANIA_08412
Module 1
A specificity: L-tyrosin; L-phenylalanine; L-tryptophan; L-4-fluorophenylalanine
Evidence for specificity: Activity assay
C domain subtype: Unknown
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
ANIA_08412
Iterative PKS subtype:
Highly reducing
3
Thioesterase type:
None
Release / cyclization type:
Unknown

Gene cluster description

aspyridone (BGC0000959). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank BN001305, positions 383588-417319. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays, Heterologous expression, Other
MIxS-compliance:Unknown
Contact for this cluster:Yuta Tsunematsu (University of Shizuoka)

Literature references

1. Bergmann S et al. (2007) Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol 3(4):213-7. doi: 10.1038/nchembio869. Epub 2007 Mar 18.
2. Xu W et al. (2010) Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae. J Am Chem Soc 132(39):13604-7. doi: 10.1021/ja107084d.