BGC0000962: barbamide biosynthetic gene cluster from Lyngbya majuscula
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 40,156 nt. (total: 40,156 nt).
This entry is originally from NCBI GenBank AF516145.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000962
Short description barbamide biosynthetic gene cluster from Lyngbya majuscula
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AF516145.1
Compounds
  • barbamide
Species Lyngbya majuscula [taxonomy]
References
Chemical products information
barbamide
Copy SMILES
C20H23Cl3N2O2S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAN32974.1
  • barA
 5531 - 5818 (+) BarA
copy AA seq
copy Nt seq
  • AAN32975.1
  • barB1
 5850 - 6752 (+) BarB1
copy AA seq
copy Nt seq
  • AAN32976.1
  • barB2
 6812 - 7705 (+) BarB2
copy AA seq
copy Nt seq
  • AAN32977.1
  • barC
 7859 - 8665 (+) BarC
copy AA seq
copy Nt seq
  • AAN32978.1
  • barD
 8700 - 10253 (+) BarD
copy AA seq
copy Nt seq
  • AAN32979.1
  • barE
 10313 - 15433 (+) BarE
copy AA seq
copy Nt seq
  • AAN32980.1
  • barF
 15476 - 16990 (+) BarF
copy AA seq
copy Nt seq
  • AAN32981.1
  • barG
 16987 - 25650 (+) BarG
copy AA seq
copy Nt seq
  • AAN32982.1
  • barH
 25696 - 26778 (+) BarH
copy AA seq
copy Nt seq
  • AAN32983.1
  • barI
 27013 - 28806 (-) BarI
copy AA seq
copy Nt seq
  • AAN32984.1
  • barJ
 28816 - 30285 (-) BarJ
copy AA seq
copy Nt seq
  • AAN32985.1
  • barK
 30616 - 31677 (-) BarK
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
barD Synthase subclass: Modular type I
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: barD
Core domains: Ketosynthase, Acyltransferase
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
barD
Module 1
Specificity: (4S)-5,5,5-trichloroleucine
Evidence for specificity:
  • Activity assay
barE
Module 2
Modification domains: Methylation
barG
Module 3
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Methylation
Module 4
Specificity: cysteine
Evidence for specificity:
  • Activity assay
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Removed TE-domain containing gene from NRP module information
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.