BGC0000964: burkholdac A biosynthetic gene cluster from Burkholderia thailandensis E264
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Location: 2,655,707 - 2,694,284 nt. (total: 38,578 nt).
This entry is originally from NCBI GenBank CP000086.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000964
Short description burkholdac A biosynthetic gene cluster from Burkholderia thailandensis E264
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
CP000086.1
2655707 - 2694284
via Gene expression correlated with compound production
Compounds
  • burkholdac A
  • burkholdac B
Species Burkholderia thailandensis E264 [taxonomy]
References
Chemical products information
burkholdac A Evidence:
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C22H35N3O6S3
burkholdac B Evidence:
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C23H37N3O6S3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BTH_I2357
  • ABC39254.1
 2655707 - 2656543 (-) thioesterase type II
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    • BTH_I2358
    • ABC38006.1
    		 2656540 - 2657460 (-) lipase/esterase
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      • BTH_I2359
      • ABC38333.1
      		 2657527 - 2658501 (-) pyridine nucleotide-disulphide oxidoreductase, class II
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        • BTH_I2360
        • ABC38000.1
        		 2658514 - 2660745 (-) nonribosomal peptide synthetase, putative
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          • BTH_I2361
          • ABC38018.1
          		 2660742 - 2661710 (-) phosphotransferase enzyme family protein, putative
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            • BTH_I2362
            • ABC37307.1
            		 2661707 - 2662879 (-) acyl-CoA dehydrogenase domain protein
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              • BTH_I2363
              • ABC38101.1
              		 2662872 - 2667449 (-) polyketide synthase
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                • BTH_I2364
                • ABC36785.1
                		 2667446 - 2678398 (-) peptide synthetase, putative
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                  • BTH_I2365
                  • ABC36687.1
                  		 2678395 - 2681949 (-) polyketide synthase
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                    • BTH_I2366
                    • ABC38737.1
                    		 2681946 - 2686628 (-) polyketide synthase
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                      • BTH_I2367
                      • ABC39418.1
                      		 2686625 - 2691724 (-) dihydroaeruginoic acid synthetase
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                        • BTH_I2368
                        • ABC36453.1
                        		 2692046 - 2692255 (-) hypothetical protein
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                          • BTH_I2369
                          • ABC37158.1
                          		 2693178 - 2694284 (+) transcriptional regulator, AraC family domain protein
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            1
                            Type
                            nrps-type1
                            Genes
                            BTH_I2367
                            Substrates
                            cysteine (evidence: Structure-based inference)
                            Integrated Monomers
                            Domains
                            condensation (Heterocyclization), adenylation
                            Name
                            4
                            Type
                            nrps-type1
                            Genes
                            BTH_I2364
                            Substrates
                            methionine (evidence: Structure-based inference)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation, epimerase
                            Name
                            5
                            Type
                            nrps-type1
                            Genes
                            BTH_I2364
                            Substrates
                            cysteine (evidence: Structure-based inference)
                            Integrated Monomers
                            Domains
                            condensation (Dual), adenylation, epimerase
                            Name
                            6
                            Type
                            nrps-type1
                            Genes
                            BTH_I2364
                            Substrates
                            isoleucine (evidence: Structure-based inference)
                            Integrated Monomers
                            Domains
                            condensation (DCL), adenylation, epimerase
                            Name
                            0
                            Type
                            pks-trans-at-starter
                            Genes
                            BTH_I2367
                            Substrates
                            Integrated Monomers
                            Domains
                            ligase
                            Name
                            2
                            Type
                            pks-trans-at
                            Genes
                            BTH_I2366
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                            Name
                            3
                            Type
                            pks-trans-at
                            Genes
                            BTH_I2365
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                            Name
                            7
                            Type
                            pks-trans-at
                            Genes
                            BTH_I2363
                            Substrates
                            Integrated Monomers
                            Domains
                            ketosynthase, ketoreductase, epimerase, carrier (ACP)
                            Annotation changelog

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Add new compound: burkholdac B
                            • (ID: H5KVDLSVQ3TJW7SKCDNBDEVC)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Corrected NRP module activity
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Removed annotations for missing genes
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Updated bioactivity data
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Updated NRP substrate specificities
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: WBX64IC5EUFODOV2ECKGLTGC)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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