BGC0000964: burkholdac A biosynthetic gene cluster from Burkholderia thailandensis E264
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 2,655,707 - 2,694,284 nt. (total: 38,578 nt).
This entry is originally from NCBI GenBank CP000086.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
other genes
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000964
Short description burkholdac A biosynthetic gene cluster from Burkholderia thailandensis E264
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide (Ansamycin)
Loci NCBI GenBank: CP000086.1
Compounds
  • burkholdac A
Species Burkholderia thailandensis E264 [taxonomy]
References
Chemical products information
burkholdac A [synonyms: thailandepsin c]
Copy SMILES
C22H35N3O6S3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BTH_I2357
  • ABC39254.1
2655707 - 2656543 (-) thioesterase type II
copy AA seq
copy Nt seq
  • BTH_I2358
  • ABC38006.1
2656540 - 2657460 (-) lipase/esterase
copy AA seq
copy Nt seq
  • BTH_I2359
  • ABC38333.1
2657527 - 2658501 (-) pyridine nucleotide-disulphide oxidoreductase, class II
copy AA seq
copy Nt seq
  • BTH_I2360
  • ABC38000.1
2658514 - 2660745 (-) nonribosomal peptide synthetase, putative
copy AA seq
copy Nt seq
  • BTH_I2361
  • ABC38018.1
2660742 - 2661710 (-) phosphotransferase enzyme family protein, putative
copy AA seq
copy Nt seq
  • BTH_I2362
  • ABC37307.1
2661707 - 2662879 (-) acyl-CoA dehydrogenase domain protein
copy AA seq
copy Nt seq
  • BTH_I2363
  • ABC38101.1
2662872 - 2667449 (-) polyketide synthase
copy AA seq
copy Nt seq
  • BTH_I2364
  • ABC36785.1
2667446 - 2678398 (-) peptide synthetase, putative
copy AA seq
copy Nt seq
  • BTH_I2365
  • ABC36687.1
2678395 - 2681949 (-) polyketide synthase
copy AA seq
copy Nt seq
  • BTH_I2366
  • ABC38737.1
2681946 - 2686628 (-) polyketide synthase
copy AA seq
copy Nt seq
  • BTH_I2367
  • ABC39418.1
2686625 - 2691724 (-) dihydroaeruginoic acid synthetase
copy AA seq
copy Nt seq
  • BTH_I2368
  • ABC36453.1
2692046 - 2692255 (-) hypothetical protein
copy AA seq
copy Nt seq
  • BTH_I2369
  • ABC37158.1
2693178 - 2694284 (+) transcriptional regulator, AraC family domain protein
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Ansamycin
Starter unit Malonyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
ABC38737.1
+
ABC39418.1
+
ABC38101.1
+
ABC36687.1
Synthase subclass: Trans-AT type I
Module 0
Specificity: Malonyl-CoA
Genes: ABC39418.1
Core domains: CoA-ligase
Module 2
Genes: ABC38737.1
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Module 3
Genes: ABC36687.1
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Module 7
Genes: ABC38101.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP), Epimerization
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactamization
Thioesterase genes
  • yp_442881 (Type I)
  • 83720112 (Type I)
  • 3849184 (Type I)
NRP-synthases
Gene Modules
ABC39418.1
Module 1
Specificity: Cysteine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
ABC36785.1
Module 4
Specificity: Methionine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 5
Specificity: Cysteine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 6
Specificity: Isoleucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
ABC38000.1
Module 8
Condensation domain type: DCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: WBX64IC5EUFODOV2ECKGLTGC, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains