BGC0000967: calyculin A biosynthetic gene cluster from uncultured Candidatus Entotheonella sp.
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 1 - 148,229 nt. (total: 148,229 nt).
This entry is originally from NCBI GenBank AB933566.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
other genes
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000967
Short description calyculin A biosynthetic gene cluster from uncultured Candidatus Entotheonella sp.
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AB933566.1
Compounds
  • calyculin A
  • phosphocalyculin A
  • calyculinamide A
  • dephosphonocalyculin A
Species uncultured Candidatus Entotheonella sp. [taxonomy]
References
Chemical products information
calyculin A
Copy SMILES
C50H81N4O15P1
Chemical database entries
PubCHEM
phosphocalyculin A
Copy SMILES
C50H82N4O18P2
calyculinamide A
Copy SMILES
C50H83N4O16P1
Chemical database entries
PubCHEM
ChemSpider
dephosphonocalyculin A
Copy SMILES
C50H80N4O12
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAP05573.1
  • calY
1 - 2364 (+) calY
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05574.1
  • calX
2395 - 2643 (+) calX
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05575.1
  • calW
2621 - 3850 (+) calW
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05576.1
  • calV
4030 - 4428 (+) calV
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05577.1
  • calU
4425 - 6545 (+) calU
  • Transport
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05578.1
  • calT
6647 - 7921 (+) calT
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05579.1
  • calS
7909 - 8715 (+) calS
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05580.1
  • calR
8708 - 9445 (+) calR
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05581.1
  • calQ
9473 - 10606 (+) calQ
  • Tailoring (Phosphorylation)
Activity assay
copy AA seq
copy Nt seq
  • BAP05582.1
  • calP
10603 - 11298 (+) calP
  • Tailoring (Phosphorylation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05583.1
  • calO
11313 - 12122 (-) calO
  • Resistance/immunity
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05584.1
  • calN
12379 - 13650 (-) calN
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05585.1
  • calM
14351 - 15049 (+) calM
  • Tailoring (Phosphorylation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05586.1
  • calL
15257 - 16411 (+) calL
  • Other enzymatic
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05587.1
  • calK
16776 - 17969 (+) calK
  • Other enzymatic
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05588.1
  • calJ
18377 - 20068 (+) calJ
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05589.1
  • calA
20404 - 31761 (+) calA
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05590.1
  • calB
31828 - 51879 (+) calB
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05591.1
  • calC
51876 - 65756 (+) calC
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05592.1
  • calD
65768 - 66895 (+) calD
  • Tailoring (Monooxygenation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05593.1
  • calE
66955 - 90753 (+) calE
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05594.1
  • calF
90764 - 108340 (+) calF
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05595.1
  • calG
108337 - 125763 (+) calG
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05596.1
  • calH
125766 - 140192 (+) calH
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • BAP05597.1
  • calI
140205 - 148229 (+) calI
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Cyclic? no
Polyketide-synthases
Genes Properties Modules
BAP05573.1
+
BAP05590.1
+
BAP05594.1
+
BAP05597.1
+
BAP05593.1
+
BAP05589.1
+
BAP05591.1
+
BAP05596.1
+
BAP05595.1
Synthase subclass: Trans-AT type I
Trans-acyltansferases: BAP05573.1
Module 1
Genes: BAP05589.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 2
Genes: BAP05589.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 3
Genes: BAP05590.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 5
Genes: BAP05590.1
Core domains: Ketosynthase, Thiolation (ACP/PCP), Dehydratase, Ketoreductase, Enoylreductase
Module 6
Genes: BAP05590.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 7
Genes: BAP05590.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 9
Genes: BAP05591.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Oxidation
Module 10
Genes: BAP05591.1
Core domains: Ketosynthase, Thiolation (ACP/PCP), Dehydratase, Ketoreductase
Scaffold-modifying domains: Oxidation
Module 11
Genes: BAP05591.1
Core domains: Ketosynthase, Thiolation (ACP/PCP), Ketoreductase
Scaffold-modifying domains: Oxidation
Module 12
Genes: BAP05593.1
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 13
Genes: BAP05593.1
Core domains: Ketosynthase
Module 14
Genes: BAP05593.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Module 15
Genes: BAP05593.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Module 16
Genes: BAP05593.1
Core domains: Ketosynthase
Module 17
Genes: BAP05593.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 18
Genes: BAP05593.1
Core domains: Ketosynthase, Ketoreductase
Module 19
Genes: BAP05594.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 20
Genes: BAP05594.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Module 21
Genes: BAP05594.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 22
Genes: BAP05594.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Module 23
Genes: BAP05594.1
Core domains: Ketosynthase, Ketoreductase
Module 23
Genes: BAP05595.1
Core domains: Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 24
Genes: BAP05595.1
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 25
Genes: BAP05595.1
Core domains: Ketosynthase
Scaffold-modifying domains: Methylation
Module 26
Genes: BAP05595.1
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 27
Genes: BAP05595.1
Core domains: Ketosynthase
Scaffold-modifying domains: Methylation
Module 28
Genes: BAP05596.1
Core domains: Ketosynthase
Scaffold-modifying domains: Beta-branching
Module 30
Genes: BAP05596.1
Core domains: Ketosynthase, Dehydratase, Ketoreductase
Scaffold-modifying domains: Beta-branching
Module 31
Genes: BAP05596.1
Core domains: Ketosynthase
Scaffold-modifying domains: Beta-branching
Module 31
Genes: BAP05597.1
Core domains: Dehydratase, Thiolation (ACP/PCP)
Module 32
Genes: BAP05597.1
Core domains: Ketosynthase
NRP-specific information
Subclass n/a
Cyclic? no
Thioesterase genes
  • BAP05597.1 (Type I)
NRP-synthases
Gene Modules
BAP05589.1
Module 0
Specificity: Serine
Evidence for specificity:
  • Sequence-based prediction
Modification domains: Methylation
BAP05590.1
Module 4
Specificity: Glycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 8
Condensation domain type: LCL
Modification domains: Unknown
BAP05591.1
Module 8
Specificity: Serine
Evidence for specificity:
  • Sequence-based prediction
BAP05596.1
Module 29
Specificity: Alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
BAP05597.1
Module 33
Specificity: Serine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: CUIZDUBUBVAF27VHF4OZXTI3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains