BGC0000968 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000968 (Penicillium expansum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS,T1PKS	1	25,930	High	chaetoglobosin A/chaetoglobosin C	NRPS:Type I+PKS:Iterative type I

BGC0000968 - Region 1 - NRPS,T1PKS

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Location: 1 - 25,930 nt. (total: 25,930 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,931
Label		BGC0000968

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

cheB: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

cheD: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

cheE: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

cheG: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Ligases: synthase

cheA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000968.5	2.00	NRPS, PKS	chaetoglobosin A, chaetoglobosin C	Penicillium expansum
BGC0001268.4	0.94	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001254.3	0.93	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.93	PKS	FR901512	fungal sp. No.14919
BGC0002230.2	0.73	NRPS, PKS	tolypyridone C	Tolypocladium sp. 49Y
BGC0002191.2	0.64	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002035.3	0.52	NRPS, PKS	ilicicolin H, ilicicolin J, 8-epi-ilicicolin H	Neonectria sp. DH2
BGC0001136.4	0.49	NRPS, PKS	desmethylbassianin	Beauveria bassiana
BGC0001305.4	0.47	PKS	fujikurin A, fujikurin B, fujikurin C, fujikurin D	Fusarium fujikuroi IMI 58289
BGC0002185.2	0.43	PKS	gregatin A	Penicillium sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000968.5	1.00	NRPS, PKS	chaetoglobosin A, chaetoglobosin C	Penicillium expansum
BGC0001268.4	0.77	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001254.3	0.76	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.76	PKS	FR901512	fungal sp. No.14919
BGC0002230.2	0.69	NRPS, PKS	tolypyridone C	Tolypocladium sp. 49Y
BGC0002191.2	0.65	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002035.3	0.59	NRPS, PKS	ilicicolin H, ilicicolin J, 8-epi-ilicicolin H	Neonectria sp. DH2
BGC0001136.4	0.58	NRPS, PKS	desmethylbassianin	Beauveria bassiana
BGC0001305.4	0.57	PKS	fujikurin A, fujikurin B, fujikurin C, fujikurin D	Fusarium fujikuroi IMI 58289
BGC0002185.2	0.54	PKS	gregatin A	Penicillium sp.

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 25930:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk - Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

cheA: pk - Trp

Search NORINE for peptide: strict or relaxed

PKS_AT (551..867): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 90.6
Methoxymalonyl-CoA: 80.2
Ethylmalonyl-CoA: 63.5
Isobutyryl-CoA: 52.9
Benzoyl-CoA: 50.1
Malonyl-CoA: 48.7
Propionyl-CoA: 40.0
2-Methylbutyryl-CoA: 25.5
CHC-CoA: 24.2
trans-1,2-CPDA: 22.1
fatty_acid: 21.7
Acetyl-CoA: 21.5
3-Methylbutyryl-CoA: 13.6
inactive: 10.8

AMP-binding (3034..3441): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMIICGCAAK
Nearest Stachelhaus code(s):: Trp DMIICGCAAK (100% 8Å match); Tyr DMIICGCAAK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor