BGC0000968: chaetoglobosin A biosynthetic gene cluster from Penicillium expansum
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Location: 1 - 25,930 nt. (total: 25,930 nt).
This entry is originally from NCBI GenBank AM779763.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000968
Short description chaetoglobosin A biosynthetic gene cluster from Penicillium expansum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AM779763.1
Compounds
  • chaetoglobosin A
  • chaetoglobosin C
Species Penicillium expansum [taxonomy]
References
Chemical products information
chaetoglobosin A
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C34H40N2O5
Chemical database entries
NPAtlas
chaetoglobosin C
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C32H36N2O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAO91859.1
  • cheC
 1 - 2204 (+) putative transcription factor
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  • CAO91860.1
  • cheB
 2478 - 3661 (-) putative enoyl reductase
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  • CAO91861.1
  • cheA
 4198 - 16239 (+) PKS-NRPS hybrid
  • Scaffold biosynthesis
Other in vivo study
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  • CAO91862.1
  • cheD
 16833 - 18776 (-) putative monooxygenase
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  • CAO91863.1
  • cheE
 19231 - 21209 (+) putative monooxygenase
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  • CAO91864.1
  • cheF
 21322 - 23755 (-) putative transcription factor
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  • CAO91865.1
  • cheG
 24298 - 25930 (-) putative monooxygenase
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
cheA Synthase subclass: Iterative type I
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 8
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
cheA
Module 1
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: ZUAEFEJPIFGA5SNZGJWBG3IU, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Hidden contributor (ID: H5KVDLSVQ3TJW7SKCDNBDEVC, no GDPR consent given).
  • Change compound name chaetoglobosins -> chaetoglobosin A (npatlas:NPA013078)
  • Added new compound: chaetoglobosin C (npatlas:NPA017501)
  • Corrected NRP module activity
  • Corrected gene identifiers
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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