BGC0000969: chondramide A biosynthetic gene cluster from Chondromyces crocatus
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Location: 1 - 49,145 nt. (total: 49,145 nt).
This entry is originally from NCBI GenBank AM179409.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000969
Short description chondramide A biosynthetic gene cluster from Chondromyces crocatus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide (Other)
Loci NCBI GenBank: AM179409.1
Compounds
  • chondramide A
Species Chondromyces crocatus [taxonomy]
References
Chemical products information
chondramide A
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C36H46N4O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAJ46687.1
 531 - 1877 (+) hypothetical protein
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  • CAJ46688.1
 2262 - 3953 (+) putative phosphoenol pyruvate synthase
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  • CAJ46689.1
  • cmdA
 3967 - 16515 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAJ46690.1
  • cmdB
 16512 - 23108 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAJ46691.1
  • cmdC
 23105 - 26461 (+) non-ribosomal peptide synthase
  • Scaffold biosynthesis
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  • CAJ46692.1
  • cmdD
 26668 - 38406 (+) non-ribosomal peptide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAJ46693.1
  • cmdE
 38459 - 40027 (+) tryptophan halogenase
  • Tailoring (Halogenation)
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  • CAJ46694.1
  • cmdF
 40179 - 41774 (+) tyrosine aminomutase
  • Precursor biosynthesis
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  • CAJ46695.1
 41795 - 42673 (+) putative phosphoenol pyruvate synthase
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  • CAJ46696.1
 42765 - 44243 (-) putative nucleotidase-2',3'-cyclic phosphodiesterase
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  • CAJ46697.1
 44408 - 45397 (+) hypothetical protein
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  • CAJ46698.1
 45410 - 46171 (+) putative cephalosporin hydroxylase
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  • CAJ46699.1
 46182 - 48533 (-) putative heavy metal translocating P-type ATPase
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
cmdB
+
cmdA 		Synthase subclass: Modular type I
Module 0
Specificity: Acetyl-CoA
Evidence for specificity: Structure-based inference
Genes: cmdA
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: cmdA
Core domains: Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 2
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: cmdA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 3
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: cmdB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactonization
Thioesterase genes
  • cmdD (Unknown)
NRP-synthases
Gene Modules
cmdC
Module 4
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
cmdD
Module 5
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
Condensation domain type: LCL
Modification domains: Methylation
Module 6
Specificity: R-beta-tyrosine / tyrosine / phenylalanine
Evidence for specificity:
  • ATP-PPi exchange assay
Genes encoding specified AA: cmdF
Condensation domain type: DCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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