Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000969.1:
Cluster 1NRP / Polyketide149145

BGC0000969, chondramide biosynthetic gene cluster from Chondromyces crocatus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Chondramid A
SMILES string: Copy to clipboard
Molecular formula: C36H46N4O7
Exact molecular mass: 647.344 Da ([M+H]+)
Molecular activity: Cytotoxic
Molecular target: actin

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Cyclic depsipeptide (cyclic)
Thioesterase type:
None
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
cmdC (CAJ46691.1)
Module 4
A specificity: Alanine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
cmdD (CAJ46692.1)
Module 5
A specificity: Tryptophan
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: LCL
Scaffold-modifying domain: Methylation
Module 6
A specificity: (R)-bTyr
Evidence for specificity: Activity assay
Amino acid biosynthesis subcluster: caj46694.1
C domain subtype: DCL
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Acetyl-CoA
Thioesterase type:
None
Release / cyclization type:
Macrolactonization

Modular polyketide synthases:
cmdA (CAJ46689.1)
Module 0
AT specificity: Acetyl-CoA
Evidence for specificity: Structure-based inference
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module 2
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group

cmdB (CAJ46690.1)
Module 3
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group

Gene cluster description

chondramide (BGC0000969). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank AM179409, positions 1-49145. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Daniel Krug (Helmholtz Institute for Pharmaceutical Research Saarland)

Literature references

1. Rachid S et al. (2006) Molecular and biochemical studies of chondramide formation-highly cytotoxic natural products from Chondromyces crocatus Cm c5. Chem Biol 13(6):667-81. doi: 10.1016/j.chembiol.2006.06.002.