BGC0000970: chondrochloren A biosynthetic gene cluster from Chondromyces crocatus
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Location: 1 - 51,243 nt. (total: 51,243 nt).
This entry is originally from NCBI GenBank AM988861.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000970
Short description chondrochloren A biosynthetic gene cluster from Chondromyces crocatus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AM988861.1
Compounds
  • chondrochloren A
Species Chondromyces crocatus [taxonomy]
References
Chemical products information
chondrochloren A
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C27H40Cl1N1O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAQ43071.1
 143 - 1522 (+) hypothetical protein
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  • CAQ43072.1
 1611 - 3041 (+) hypothetical protein
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  • CAQ43073.1
  • cndI
 3129 - 5231 (-) radical SAM methyltransferase
  • Tailoring (Methylation)
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  • CAQ43074.1
  • cndH
 5294 - 6832 (-) halogenase
  • Tailoring (Halogenation)
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  • CAQ43075.1
  • cndA
 7497 - 16268 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ43076.1
  • cndB
 16265 - 22033 (+) polyketide synthase
  • Scaffold biosynthesis
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  • CAQ43077.1
  • cndC
 22030 - 26265 (+) polyketide synthase
  • Scaffold biosynthesis
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  • CAQ43078.1
  • cndD
 26267 - 31888 (+) polyketide synthase
  • Scaffold biosynthesis
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  • CAQ43079.1
  • cndE
 31894 - 37500 (+) polyketide synthase
  • Scaffold biosynthesis
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  • CAQ43080.1
 37581 - 38396 (+) hypothetical protein
  • Precursor biosynthesis
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  • CAQ43081.1
 38434 - 38706 (+) hypothetical protein
  • Precursor biosynthesis
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  • CAQ43082.1
 38736 - 39869 (+) hypothetical protein
  • Precursor biosynthesis
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  • CAQ43083.1
 39877 - 41037 (+) hypothetical protein
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  • CAQ43084.1
  • cndF
 41034 - 45236 (+) non ribosomal polypeptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ43085.1
  • cndG
 45233 - 46858 (+) chondrochloren decarboxylase
  • Tailoring (Decarboxylation)
Sequence-based prediction
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  • CAQ43086.1
 46865 - 48337 (-) hypothetical protein
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  • CAQ43087.1
 48363 - 49601 (-) hypothetical protein
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  • CAQ43088.1
 49773 - 50843 (-) hypothetical protein
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Polyketide-specific information
Subclass Other
Starter unit Butyryl-ACP
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
cndB
+
cndC
+
cndA
+
cndD
+
cndE 		Synthase subclass: Modular type I
Module 1
Genes: cndA
Core domains: CoA-ligase, Thiolation (ACP/PCP)
Module 2
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: cndA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 3
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: cndB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 4
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: cndC
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Thiolation (ACP/PCP)
Module 5
Specificity: Hydroxymalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: cndD
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 6
Specificity: Hydroxymalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: cndE
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Hydrolysis
NRP-synthases
Gene Modules
cndF
Module 7
Specificity: 3-chlorotyrosine / tyrosine
Evidence for specificity:
  • ATP-PPi exchange assay
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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