BGC0000970: chondrochloren A biosynthetic gene cluster from Chondromyces crocatus
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Location: 1 - 51,243 nt. (total: 51,243 nt).
This entry is originally from NCBI GenBank AM988861.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000970
Short description chondrochloren A biosynthetic gene cluster from Chondromyces crocatus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
AM988861.1
via Knock-out studies
Compounds
  • chondrochloren A
Species Chondromyces crocatus [taxonomy]
References
Chemical products information
chondrochloren A Evidence:
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C27H40Cl1N1O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAQ43071.1
 143 - 1522 (+) hypothetical protein
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    • CAQ43072.1
    		 1611 - 3041 (+) hypothetical protein
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      • CAQ43073.1
      • cndI
      		 3129 - 5231 (-) radical SAM methyltransferase
      • Tailoring
      • Knock-out
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      • CAQ43074.1
      • cndH
      		 5294 - 6832 (-) halogenase
      • Tailoring
      • Knock-out
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      • CAQ43075.1
      • cndA
      		 7497 - 16268 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAQ43076.1
      • cndB
      		 16265 - 22033 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAQ43077.1
      • cndC
      		 22030 - 26265 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAQ43078.1
      • cndD
      		 26267 - 31888 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAQ43079.1
      • cndE
      		 31894 - 37500 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAQ43080.1
      		 37581 - 38396 (+) hypothetical protein
      • Precursor biosynthesis
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      • CAQ43081.1
      		 38434 - 38706 (+) hypothetical protein
      • Precursor biosynthesis
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      • CAQ43082.1
      		 38736 - 39869 (+) hypothetical protein
      • Precursor biosynthesis
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      • CAQ43083.1
      		 39877 - 41037 (+) hypothetical protein
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        • CAQ43084.1
        • cndF
        		 41034 - 45236 (+) non ribosomal polypeptide synthetase
        • Scaffold biosynthesis
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        • CAQ43085.1
        • cndG
        		 45233 - 46858 (+) chondrochloren decarboxylase
        • Tailoring
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        • CAQ43086.1
        		 46865 - 48337 (-) hypothetical protein
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          • CAQ43087.1
          		 48363 - 49601 (-) hypothetical protein
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            • CAQ43088.1
            		 49773 - 50843 (-) hypothetical protein
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              Biosynthesis information

              Biosynthetic modules

              Name
              7
              Type
              nrps-type1
              Genes
              cndF
              Substrates
              3-chlorotyrosine, tyrosine (evidence: ATP-PPi exchange assay [1])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              1
              Type
              pks-trans-at-starter
              Genes
              cndA
              Substrates
              Integrated Monomers
              Domains
              ligase, carrier (ACP)
              Name
              2
              Type
              pks-modular
              Genes
              cndA
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
              Name
              3
              Type
              pks-modular
              Genes
              cndB
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
              Name
              4
              Type
              pks-modular
              Genes
              cndC
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, dehydratase, carrier (ACP)
              Name
              5
              Type
              pks-modular
              Genes
              cndD
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
              Name
              6
              Type
              pks-modular
              Genes
              cndE
              Substrates
              Integrated Monomers
              Domains
              acyltransferase, ketosynthase, acyltransferase, ketoreductase, methyltransferase, carrier (ACP)
              Annotation changelog

              Entry version: 4

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 3

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Corrected NRP module activity
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Removed ketoreductase stereochemistry annotation from modules without ketoreductases
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Updated bioactivity data
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Updated NRP substrate specificities
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2019-10-16
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2019-10-16
              Updated compound(s) information (NPAtlas curation)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2015-06-12
              Submitted
              • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
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