Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000970.1:
Cluster 1NRP / Polyketide151243

BGC0000970, chondrochloren biosynthetic gene cluster from Chondromyces crocatus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Chondrochloren
SMILES string: Copy to clipboard
Molecular formula: C27H40Cl1N1O7
Exact molecular mass: 526.2566 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
Type I
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
cndF (CAQ43084.1)
Module 7
A specificity: Tyrosine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Butyryl-ACP
Thioesterase type:
None
Release / cyclization type:
Hydrolysis

Modular polyketide synthases:
cndA (CAQ43075.1)
Module 1
AT specificity: Unknown
Evidence for specificity: Unknown
Module 2
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

cndB (CAQ43076.1)
Module 3
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group

cndC (CAQ43077.1)
Module 4
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference

cndD (CAQ43078.1)
Module 5
AT specificity: Hydroxymalonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: B-group

cndE (CAQ43079.1)
Module 6
AT specificity: Hydroxymalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation

Gene cluster description

chondrochloren (BGC0000970). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank AM988861, positions 1-51243. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Rachid S et al. (2009) Unusual chemistry in the biosynthesis of the antibiotic chondrochlorens. Chem Biol 16(1):70-81. doi: 10.1016/j.chembiol.2008.11.005.