BGC0000971: cinnabaramide A biosynthetic gene cluster from Streptomyces cinnabarigriseus
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Location: 1 - 29,932 nt. (total: 29,932 nt).
This entry is originally from NCBI GenBank FR687018.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000971
Short description cinnabaramide A biosynthetic gene cluster from Streptomyces cinnabarigriseus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
FR687018.1
via Knock-out studies
Compounds
  • cinnabaramide A
Species Streptomyces cinnabarigriseus [taxonomy]
References
Chemical products information
cinnabaramide A Evidence:
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C19H29N1O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CBW54656.1
 94 - 1170 (+) putative methylase
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    • CBW54657.1
    		 1378 - 1983 (+) hypothetical protein
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      • CBW54658.1
      		 2030 - 3004 (+) putative P450
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        • CBW54659.1
        		 3234 - 4205 (+) LuxR like regulator
        • Regulation
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        • CBW54660.1
        		 4385 - 6157 (+) Acyl-CoA ligase
        • Activation / processing
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        • CBW54661.1
        		 6157 - 7152 (+) 3-oxo-acyl (ACP) synthase
        • Activation / processing
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        • CBW54662.1
        		 7398 - 8741 (+) phenyl-acetate-CoA ligase
        • Activation / processing
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        • CBW54663.1
        		 8741 - 9736 (+) L-amino acid aminotransferase
        • Scaffold biosynthesis
        • Knock-out
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        • CBW54664.1
        		 9733 - 10350 (+) hypothetical protein
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          • CBW54665.1
          		 10384 - 11373 (+) ornithine cyclodeaminase
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            • CBW54666.1
            		 11417 - 11704 (+) hypothetical protein
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              • CBW54667.1
              		 11701 - 12543 (+) phenazine biosynthesis protein
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                • CBW54668.1
                		 12976 - 14184 (+) putative cytochrome P450
                • Tailoring
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                • CBW54669.1
                		 14213 - 14410 (+) ferredoxin-2
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                  • CBW54670.1
                  		 14472 - 15317 (-) 20S proteasome beta-subunit
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                    • CBW54671.1
                    • cinA
                    		 15573 - 21695 (+) polyketide synthase/non ribosomal peptide synthetase
                    • Scaffold biosynthesis
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                    • CBW54672.1
                    • cinB
                    		 21692 - 23530 (+) non ribosomal peptide synthetase
                    • Scaffold biosynthesis
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                    • CBW54673.1
                    • cinC
                    		 23558 - 25348 (+) ketosynthase
                    • Scaffold biosynthesis
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                    • CBW54674.1
                    • cinD
                    		 25399 - 26643 (+) cytochrome P450
                    • Tailoring
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                    • CBW54675.1
                    • cinE
                    		 26657 - 27481 (+) thioesterase
                    • Scaffold biosynthesis
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                    • CBW54676.1
                    • cinF
                    		 27492 - 28838 (+) octenoyl-CoA reductase/carboxylase
                    • Precursor biosynthesis
                    • Knock-out
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                    • CBW54677.1
                    		 28896 - 29897 (-) LysR like regulator
                    • Regulation
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                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    2
                    Type
                    nrps-type1
                    Genes
                    cinB
                    Substrates
                    S-beta-hydroxycyclohex-2S-enylalanine (evidence: Structure-based inference)
                    Integrated Monomers
                    Domains
                    condensation (LCL), adenylation
                    Name
                    1
                    Type
                    pks-modular
                    Genes
                    cinA
                    Substrates
                    Integrated Monomers
                    Domains
                    acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                    Annotation changelog

                    Entry version: 4

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Update chemical activity to schema version 2.11
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Corrected NRP module activity
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Remove leading/trailing whitespace in gene identifiers
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Updated bioactivity data
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Updated NRP substrate specificities
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2019-10-16
                    Updated compound(s) information (NPAtlas curation)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2015-06-12
                    Submitted
                    • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    Detailed domain annotation
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