Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000971.1:
Cluster 1NRP / Polyketide129932

BGC0000971, cinnabaramide biosynthetic gene cluster from Streptomyces sp. JS360. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Cinnabaramide
SMILES string: Copy to clipboard
Molecular formula: C19H29N1O4
Exact molecular mass: 336.2169 Da ([M+H]+)
Molecular activity: Antifungal, Cytotoxic
Molecular target: proteasome inhibitor

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
Unknown
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
cinA (CBW54671.1)
Module 2
A specificity: None
Evidence for specificity: Unknown
C domain subtype: LCL
cinB (CBW54672.1)
Module 2
A specificity: B-OH-cyc-hex-ala
Evidence for specificity: Structure-based inference
Amino acid biosynthesis subcluster:
C domain subtype: LCL
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Acetyl-CoA
Thioesterase type:
None
Release / cyclization type:
Hydrolysis

Modular polyketide synthases:
cinA (CBW54671.1)
Module 1
AT specificity: Other
Evidence for specificity: Structure-based inference

Gene cluster description

cinnabaramide (BGC0000971). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank FR687018, positions 1-29932. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Rachid S et al. (2011) Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors. Chembiochem 12(6):922-31. doi: 10.1002/cbic.201100024. Epub 2011 Mar