BGC0000971: cinnabaramide A biosynthetic gene cluster from Streptomyces cinnabarigriseus
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Location: 1 - 29,932 nt. (total: 29,932 nt).
This entry is originally from NCBI GenBank FR687018.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000971
Short description cinnabaramide A biosynthetic gene cluster from Streptomyces cinnabarigriseus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: FR687018.1
Compounds
  • cinnabaramide A
Species Streptomyces cinnabarigriseus [taxonomy]
References
Chemical products information
cinnabaramide A
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C19H29N1O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CBW54656.1
 94 - 1170 (+) putative methylase
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  • CBW54657.1
 1378 - 1983 (+) hypothetical protein
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  • CBW54658.1
 2030 - 3004 (+) putative P450
  • Unknown
Sequence-based prediction
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  • CBW54659.1
 3234 - 4205 (+) LuxR like regulator
  • Regulation
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  • CBW54660.1
 4385 - 6157 (+) Acyl-CoA ligase
  • Activation / processing
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  • CBW54661.1
 6157 - 7152 (+) 3-oxo-acyl (ACP) synthase
  • Activation / processing
Sequence-based prediction
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  • CBW54662.1
 7398 - 8741 (+) phenyl-acetate-CoA ligase
  • Activation / processing
Sequence-based prediction
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  • CBW54663.1
 8741 - 9736 (+) L-amino acid aminotransferase
  • Scaffold biosynthesis
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  • CBW54664.1
 9733 - 10350 (+) hypothetical protein
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  • CBW54665.1
 10384 - 11373 (+) ornithine cyclodeaminase
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  • CBW54666.1
 11417 - 11704 (+) hypothetical protein
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  • CBW54667.1
 11701 - 12543 (+) phenazine biosynthesis protein
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  • CBW54668.1
 12976 - 14184 (+) putative cytochrome P450
  • Tailoring (Oxidation)
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  • CBW54669.1
 14213 - 14410 (+) ferredoxin-2
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  • CBW54670.1
 14472 - 15317 (-) 20S proteasome beta-subunit
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  • CBW54671.1
  • cinA
 15573 - 21695 (+) polyketide synthase/non ribosomal peptide synthetase
  • Scaffold biosynthesis
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  • CBW54672.1
  • cinB
 21692 - 23530 (+) non ribosomal peptide synthetase
  • Scaffold biosynthesis
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  • CBW54673.1
  • cinC
 23558 - 25348 (+) ketosynthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CBW54674.1
  • cinD
 25399 - 26643 (+) cytochrome P450
  • Tailoring (Oxidation)
Sequence-based prediction
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  • CBW54675.1
  • cinE
 26657 - 27481 (+) thioesterase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CBW54676.1
  • cinF
 27492 - 28838 (+) octenoyl-CoA reductase/carboxylase
  • Precursor biosynthesis
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  • CBW54677.1
 28896 - 29897 (-) LysR like regulator
  • Regulation
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
cinA Synthase subclass: Modular type I
Module 1
Genes: cinA
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Hydrolysis
NRP-synthases
Gene Modules
cinA
Module 2
Condensation domain type: LCL
cinB
Module 2
Specificity: S-beta-hydroxycyclohex-2S-enylalanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Remove leading/trailing whitespace in gene identifiers
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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