Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000973.1:
Cluster 1NRP / Polyketide146672

BGC0000973, collismycin A biosynthetic gene cluster from Streptomyces sp. CS40. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: collismycin A
SMILES string: Copy to clipboard
Molecular formula: C13H13N3O2S
Exact molecular mass: 276.33 Da ([M+H]+)
Molecular activity: Other

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (cyclic)
Thioesterase type:
Type II
Release / cyclization type:

Nonribosomal peptide synthetases:
clmN1 (CCC55921.1)
Module 2
A specificity: Cysteine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: Unknown
Scaffold-modifying domain: Cyclase
clmN2 (CCC55922.1)
Module 3
A specificity: Leucine
Evidence for specificity: Other
C domain subtype: Unknown
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Thioesterase type:
Release / cyclization type:

Modular polyketide synthases:
clmP (CCC55918.1)
Module 0

clmN1 (CCC55921.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction

Gene cluster description

collismycin A (BGC0000973). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank HE575208. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
Contact for this cluster:Jose A. Salas (University of Oviedo)

Literature references

1. Garcia I et al. (2012) Elucidating the biosynthetic pathway for the polyketide-nonribosomal peptide collismycin A: mechanism for formation of the 2,2'-bipyridyl ring. Chem Biol 19(3):399-413. doi: 10.1016/j.chembiol.2012.01.014.