BGC0000973: collismycin A biosynthetic gene cluster from Streptomyces sp. CS40
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Location: 1 - 46,672 nt. (total: 46,672 nt).
This entry is originally from NCBI GenBank HE575208.1.

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core biosynthetic genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000973
Short description collismycin A biosynthetic gene cluster from Streptomyces sp. CS40
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: HE575208.1
Compounds
  • collismycin A
Species Streptomyces sp. CS40 [taxonomy]
References
Chemical products information
collismycin A
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C13H13N3O2S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCC55901.1
 549 - 2237 (-) hypothetical protein
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  • CCC55902.1
  • clmR1
 2857 - 3414 (+) putative TetR transcriptional regulator
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  • CCC55903.1
  • clmT1
 3514 - 5247 (-) putative ABC transporter, ATPase and permease component
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  • CCC55904.1
  • clmT2
 5256 - 7016 (-) putative ABC transporter, ATPase and permease component
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  • CCC55905.1
  • clmT3
 7225 - 8193 (+) putative ABC transporter, solute binding protein
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  • CCC55906.1
  • clmT4
 8322 - 9305 (+) putative ABC transporter, permease component
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  • CCC55907.1
  • clmT5
 9314 - 10099 (+) putative ABC tarnsporter, ATP-binding protein
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  • CCC55908.1
  • clmR2
 10363 - 10869 (+) LuxR family transcriptional regulator
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  • CCC55909.1
  • clmM2
 11042 - 12070 (-) O-methyltransferase
  • Tailoring (Methylation)
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  • CCC55910.1
  • clmD2
 12105 - 13703 (-) putative dehydrogenase
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  • CCC55911.1
  • clmAT
 13861 - 15495 (+) putative aminotransferase
  • Tailoring (Amination)
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  • CCC55912.1
  • clmM1
 15620 - 16606 (+) S-Methyltransferase
  • Tailoring (Methylation)
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  • CCC55913.1
  • clmG1
 16688 - 18076 (-) GriD-like dehydrogenase component
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  • CCC55914.1
  • clmG2
 18078 - 19109 (-) GriC-like dehydrogenase component
  • Scaffold biosynthesis
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  • CCC55915.1
  • clmM
 19405 - 20613 (+) putative FAD dependent monooxygenase
  • Scaffold biosynthesis
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  • CCC55916.1
  • clmAH
 20680 - 21921 (-) amidohydrolase
  • Scaffold biosynthesis
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  • CCC55917.1
  • clmAL
 21926 - 23614 (-) putative acyl CoA ligase
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  • CCC55918.1
  • clmP
 23611 - 23871 (-) putative free-standing acyl carrier protein
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  • CCC55919.1
  • clmL
 24108 - 25484 (+) L-Lysine 2-aminotransferase
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  • CCC55920.1
  • clmS
 25481 - 26662 (+) monomeric sarcosine oxidase
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  • CCC55921.1
  • clmN1
 26548 - 34206 (+) non-ribosomal peptide synthetase/polyketide synthase hybrid protein
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  • CCC55922.1
  • clmN2
 34203 - 37478 (+) putative non-ribosomal peptide synthetase
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  • CCC55923.1
  • clmD1
 37475 - 38659 (+) putative acyl-CoA dehydrogenase
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  • CCC55924.1
  • clmT
 38652 - 39380 (+) putative type II thioesterase
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  • CCC55925.1
 39442 - 40665 (-) hypothetical protein
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  • CCC55926.1
 41103 - 41708 (+) hypothetical protein
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  • CCC55927.1
 42017 - 46105 (+) hypothetical protein
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Polyketide-specific information
Subclass Other
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
clmP
+
clmN1 		Synthase subclass: Modular type I
Module 0
Genes: clmP
Core domains: Thiolation (ACP/PCP)
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: clmN1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? yes
NRP-synthases
Gene Modules
clmN1
Module 2
Specificity: cysteine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
Modification domains: Cyclase
clmN2
Module 3
Specificity: leucine
Evidence for specificity:
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: IROSGRAECON7XFWB774QFHDN, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: H5KVDLSVQ3TJW7SKCDNBDEVC, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Linked new NPAtlas id for collismycin A (npatlas:NPA020595)
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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