BGC0000974: crocacin biosynthetic gene cluster from Chondromyces crocatus
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Location: 1 - 61,438 nt. (total: 61,438 nt).
This entry is originally from NCBI GenBank FN547928.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000974
Short description crocacin biosynthetic gene cluster from Chondromyces crocatus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
FN547928.1
via
Compounds
  • crocacin
Species Chondromyces crocatus [taxonomy]
References
Chemical products information
crocacin Evidence:
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C31H42N2O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CBD77727.1
 312 - 2426 (+) hypothetical protein
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    • CBD77728.1
    		 3673 - 5499 (+) hypothetical protein
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      • CBD77730.1
      		 5523 - 7367 (+) hypothetical protein
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        • CBD77732.1
        • croA
        		 7669 - 15435 (+) polyketide synthase
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          • CBD77734.1
          • croB
          		 15432 - 21140 (+) polyketide synthase
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            • CBD77736.1
            • croC
            		 21208 - 26844 (+) polyketide synthase
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              • CBD77738.1
              • croD
              		 26841 - 29633 (+) polyketide synthase
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                • CBD77739.1
                • croE
                		 29630 - 30883 (+) hydroxymethylglutaryl-coenzyme A
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                  • CBD77741.1
                  • croF
                  		 30874 - 31677 (+) enoyl-coA-hydratase/isomerase
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                    • CBD77742.1
                    • croG
                    		 31674 - 32462 (+) enoyl-coA-hydratase/isomerase
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                      • CBD77744.1
                      • croH
                      		 32449 - 32700 (+) acyl carrier protein
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                        • CBD77746.1
                        • croI
                        		 32700 - 41591 (+) non-ribosomal peptide synthetase/polyketide synthase
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                          • CBD77748.1
                          • croJ
                          		 41588 - 47272 (+) polyketide synthase
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                            • CBD77749.1
                            • croK
                            		 47269 - 51879 (+) non-ribosomal peptide synthetase
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                              • CBD77751.1
                              • croL
                              		 51991 - 52713 (+) O-methyltransferase
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                                • CBD77752.1
                                • CYP450
                                		 52781 - 54028 (-) cytochrome P450
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                                  • CBD77754.1
                                  		 54050 - 56128 (-) hypothetical protein
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                                    • CBD77756.1
                                    		 56487 - 56942 (-) hypothetical protein
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                                      • CBD77757.1
                                      • ccp
                                      		 57147 - 58493 (-) cytochrome-c peroxidase
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                                        • CBD77759.1
                                        		 58845 - 59963 (+) hypothetical protein
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                                          • CBD77761.1
                                          		 59960 - 60742 (+) hypothetical protein
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                                            Biosynthesis information

                                            Biosynthetic modules

                                            Name
                                            Unk01
                                            Type
                                            nrps-type1
                                            Genes
                                            croI
                                            Substrates
                                            glycine (evidence: )
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk02
                                            Type
                                            nrps-type1
                                            Genes
                                            croK
                                            Substrates
                                            glycine (evidence: )
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Annotation changelog

                                            Entry version: 4

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-10-07
                                            Update chemical activity to schema version 2.11
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 3

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Updated bioactivity data
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Added NRP substrate specificities
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2019-10-16
                                            Migrated from v1.4
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2019-10-16
                                            Updated compound(s) information (NPAtlas curation)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2015-06-12
                                            Submitted
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            Detailed domain annotation
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