BGC0000975: Cryptophycin A biosynthetic gene cluster from Nostoc sp. ATCC 53789
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Location: 1 - 57,306 nt. (total: 57,306 nt).
This entry is originally from NCBI GenBank EF159954.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000975
Short description Cryptophycin A biosynthetic gene cluster from Nostoc sp. ATCC 53789
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
EF159954.1
via Enzymatic assays
Compounds
  • Cryptophycin A
Species Nostoc sp. ATCC 53789 [taxonomy]
References
Chemical products information
Cryptophycin A [synonyms: Cryptophycin, Cryptophycin 1] Evidence: NMR [1]
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C35H43Cl1N2O8
Chemical database entries
CyanoMetDB CyanoMetDB_1104
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABM21569.1
  • crpA
 9964 - 18789 (+) crpA
  • Scaffold biosynthesis
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  • ABM21570.1
  • crpB
 18814 - 29223 (+) crpB
  • Scaffold biosynthesis
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  • ABM21571.1
  • crpC
 29220 - 35051 (+) crpC
  • Scaffold biosynthesis
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  • ABM21572.1
  • crpD
 35090 - 45121 (+) crpD
  • Scaffold biosynthesis
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  • ABM21573.1
  • crpE
 45180 - 46532 (+) crpE
  • Tailoring
  • Activity assay
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  • ABM21574.1
  • crpF
 46916 - 47800 (+) crpF
  • Tailoring
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  • ABM21575.1
  • crpG
 47812 - 48153 (+) crpG
  • Tailoring
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  • ABM21576.1
  • crpH
 48796 - 50271 (+) crpH
  • Tailoring
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Biosynthesis information

Biosynthetic modules

Name
4
Type
nrps-type1
Genes
crpC
Substrates
tyrosine (evidence: Structure-based inference [1], [2])
Integrated Monomers
Domains
condensation (LCL), adenylation, epimerase, methyltransferase
Name
5
Type
nrps-type1
Genes
crpD
Substrates
3R-methylbeta-alanine (evidence: Structure-based inference [1], [2])
Integrated Monomers
Domains
condensation (DCL), adenylation
Name
6
Type
nrps-type1
Genes
crpD
Substrates
2-ketoisocaproic acid (evidence: Structure-based inference [1], [2])
Integrated Monomers
Domains
condensation (LCL), adenylation
Name
0
Type
pks-trans-at-starter
Genes
crpA
Substrates
Integrated Monomers
Domains
ligase, carrier (ACP)
Name
1
Type
pks-modular
Genes
crpA
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
Name
2
Type
pks-modular
Genes
crpB
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
3
Type
pks-modular
Genes
crpB
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
Annotation changelog

Entry version: next

Date
Changes
Submitters
Reviewers
2024-06-11
MIBiG v4 annotathon
  • (ID: NHJ6M55E7ZEHUFNMEG4QIZWY)
  • (ID: 76VHR3W4632SUCCHB24QUXTZ)
  • (ID: B54ZPFB4PBVBWY2K6JZNBOD5)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Corrected NRP module activity
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Updated bioactivity data
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Updated NRP substrate specificities
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2019-10-16
Updated compound(s) information (NPAtlas curation)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
  • (ID: BAJIZJS2YANDM4M7JHS5DFUK)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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