Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000975.1:
Cluster 1NRP157306

BGC0000975, cryptophycin biosynthetic gene cluster from Nostoc sp. ATCC. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: cryptophyicin 1
PubChem ID: 6438401
SMILES string: Copy to clipboard
Molecular formula: C35H43ClN2O8
Average molecular mass: 655.185 Da
Molecular activity: Antifungal, Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP
Other (cyclic)
Thioesterase type:
None
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
crpC (ABM21571.1)
Module 4
A specificity: tyrosine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: LCL
Scaffold-modifying domain: Methylation
crpD (ABM21572.1)
Module 5
A specificity: methyl beta-alanine
Evidence for specificity: Structure-based inference
C domain subtype: DCL
Module 6
A specificity: alpha-ketoisocaproic acid
Evidence for specificity: Structure-based inference
C domain subtype: LCL

Gene cluster description

cryptophycin (BGC0000975). Gene Cluster 1. Biosynthetic class = NRP. GenBank EF159954. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:David Fewer (University of Helsinki)

Literature references

1. Magarvey NA et al. (2006) Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts. ACS Chem Biol 1(12):766-79. doi: 10.1021/cb6004307.