BGC0000976: curacin A biosynthetic gene cluster from Moorea producens 3L
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Location: 1 - 65,189 nt. (total: 65,189 nt).
This entry is originally from NCBI GenBank HQ696500.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000976
Short description curacin A biosynthetic gene cluster from Moorea producens 3L
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Thioesterase results in decarboxylation and desulfonation of the compound. "
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
HQ696500.1
via Enzymatic assays, Gene expression correlated with compound production
Compounds
  • curacin A
Species Moorea producens 3L [taxonomy]
References
Chemical products information
curacin A Evidence:
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C23H35N1O1S1
Chemical database entries
NPAtlas
PubCHEM
ChEBI
ChEMBL
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEE88276.1
 1 - 1011 (-) hypothetical protein
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    • AEE88277.1
    		 1426 - 8061 (-) CurM
    • Scaffold biosynthesis
    • Activity assay
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    • AEE88278.1
    		 8064 - 13934 (-) CurL
    • Scaffold biosynthesis
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    • AEE88279.1
    		 14019 - 20717 (-) CurK
    • Scaffold biosynthesis
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    • AEE88280.1
    		 20776 - 27672 (-) CurJ
    • Scaffold biosynthesis
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    • AEE88281.1
    		 27740 - 32710 (-) CurI
    • Scaffold biosynthesis
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    • AEE88282.1
    		 32710 - 39309 (-) CurH
    • Scaffold biosynthesis
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    • AEE88283.1
    		 39318 - 44069 (-) CurG
    • Scaffold biosynthesis
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    • AEE88284.1
    		 44157 - 53744 (-) CurF
    • Scaffold biosynthesis
    • Activity assay
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    • AEE88285.1
    		 53732 - 54496 (-) CurE
    • Tailoring
    • Activity assay
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    • AEE88286.1
    		 54753 - 56012 (-) CurD
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      • AEE88287.1
      		 56017 - 57243 (-) CurC
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        • AEE88288.1
        		 57295 - 57534 (-) CurB
        • Activation / processing
        • Activity assay
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        • AEE88289.1
        		 57553 - 64488 (-) CurA
        • Scaffold biosynthesis
        • Activity assay
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        • AEE88290.1
        		 65046 - 65189 (-) hypothetical protein
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          Biosynthesis information

          Biosynthetic modules

          Name
          4
          Type
          nrps-type1
          Genes
          AEE88284.1
          Substrates
          cysteine (evidence: Structure-based inference)
          Integrated Monomers
          Domains
          condensation, adenylation
          Name
          None
          Type
          pks-trans-at-starter
          Genes
          AEE88288.1
          Substrates
          Integrated Monomers
          Domains
          carrier (ACP)
          Name
          None
          Type
          pks-trans-at
          Genes
          AEE88287.1
          Substrates
          Integrated Monomers
          Domains
          ketosynthase
          Name
          None
          Type
          pks-trans-at-starter
          Genes
          AEE88285.1
          Substrates
          Integrated Monomers
          Domains
          enoylreductase
          Name
          0
          Type
          pks-modular-starter
          Genes
          AEE88289.1
          Substrates
          Integrated Monomers
          Domains
          acyltransferase, carrier (ACP)
          Name
          1
          Type
          pks-modular
          Genes
          AEE88289.1
          Substrates
          Integrated Monomers
          Domains
          acyltransferase, ketosynthase, acyltransferase, carrier (ACP), carrier (ACP), carrier (ACP)
          Name
          2
          Type
          pks-trans-at-starter
          Genes
          AEE88284.1
          Substrates
          Integrated Monomers
          Domains
          enoylreductase
          Name
          3
          Type
          pks-modular
          Genes
          AEE88284.1
          Substrates
          Integrated Monomers
          Domains
          acyltransferase, ketosynthase, acyltransferase, dehydratase, carrier (ACP)
          Name
          5
          Type
          pks-modular
          Genes
          AEE88283.1
          Substrates
          Integrated Monomers
          Domains
          acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
          Name
          6
          Type
          pks-modular
          Genes
          AEE88282.1
          Substrates
          Integrated Monomers
          Domains
          acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
          Name
          7
          Type
          pks-modular
          Genes
          AEE88281.1
          Substrates
          Integrated Monomers
          Domains
          acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
          Name
          8
          Type
          pks-modular
          Genes
          AEE88280.1
          Substrates
          Integrated Monomers
          Domains
          acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
          Name
          9
          Type
          pks-modular
          Genes
          AEE88279.1
          Substrates
          Integrated Monomers
          Domains
          acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
          Name
          10
          Type
          pks-modular
          Genes
          AEE88278.1
          Substrates
          Integrated Monomers
          Domains
          acyltransferase, ketosynthase, acyltransferase, ketoreductase, methyltransferase, carrier (ACP)
          Name
          11
          Type
          pks-modular
          Genes
          AEE88277.1
          Substrates
          Integrated Monomers
          Domains
          acyltransferase, ketosynthase, acyltransferase, ketoreductase, thioesterase, carrier (ACP)
          Annotation changelog

          Entry version: 4

          Date
          Changes
          Submitters
          Reviewers
          2022-10-07
          Update chemical activity to schema version 2.11
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 3

          Date
          Changes
          Submitters
          Reviewers
          2022-09-15
          Corrected NRP module activity
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Removed gene names of 'No gene ID'
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Removed ketoreductase stereochemistry annotation from modules without ketoreductases
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Sorted modules by module number
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Changed amino acid substrates to lower case
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 2

          Date
          Changes
          Submitters
          Reviewers
          2019-10-16
          Migrated from v1.4
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2019-10-16
          Updated compound(s) information (NPAtlas curation)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 1

          Date
          Changes
          Submitters
          Reviewers
          2015-06-12
          Submitted
          • (ID: SGC7EMZRHSTY2JHRE5IDTTEF)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          Detailed domain annotation
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