Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000978.1:
Cluster 1NRP / Polyketide / Alkaloid142156

BGC0000978, cylindrospermopsin biosynthetic gene cluster from Cylindrospermopsis raciborskii. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: cylindrospermopsin
PubChem ID: 115005
ChemSpider ID: 26396261
SMILES string: Copy to clipboard
Molecular formula: C15H21N5O7S
Average molecular mass: 415.421 Da
Molecular activity: Cytotoxic, Other

Class-specific details

Biosynthetic class(es):
NRP / Polyketide / Alkaloid
Other (cyclic)
Thioesterase type:
None
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
cyrB (ABX60161.1)
Module 0
A specificity: guanidinoacetate
Evidence for specificity: Activity assay
C domain subtype: N/A
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Other
Thioesterase type:
None
Release / cyclization type:
Other

Modular polyketide synthases:
cyrD (ABX60152.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

cyrF (ABX60153.1)
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None

cyrB (ABX60161.1)
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: Methylation

cyrE (ABX60162.1)
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

cyrC (ABX60163.1)
Module 5
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

Alkaloid subclass:
Other

Gene cluster description

cylindrospermopsin (BGC0000978). Gene Cluster 1. Biosynthetic class = NRP/Polyketide/Alkaloid. GenBank EU140798. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Brett Neilan (UNSW Australia)

Literature references

1. Mihali TK et al. (2008) Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis. Appl Environ Microbiol 74(3):716-22. doi: 10.1128/AEM.01988-07. Epub