BGC0000983: cytochalasin E biosynthetic gene cluster from Aspergillus clavatus NRRL 1
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Location: 334,675 - 379,692 nt. (total: 45,018 nt).
This entry is originally from NCBI GenBank DS027057.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000983
Short description cytochalasin E biosynthetic gene cluster from Aspergillus clavatus NRRL 1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
DS027057.1
334675 - 379692
via Knock-out studies
Compounds
  • cytochalasin E
  • cytochalasin K
Species Aspergillus clavatus NRRL 1 [taxonomy]
References
Chemical products information
cytochalasin E Evidence: NMR [3]
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C28H33N1O7
Chemical database entries
PubCHEM
NPAtlas
cytochalasin K Evidence: NMR [2]
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C32H37N1O6
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACLA_078610
  • EAW09112.1
 334675 - 338654 (+) sensor histidine kinase/response regulator, putative
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    • ACLA_078620
    • EAW09113.1
    		 339108 - 341077 (-) glucan 1,4-alpha-glucosidase, putative
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      • ACLA_078630
      • EAW09114.1
      		 342001 - 342585 (-) hypothetical protein
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        • ACLA_078640
        • EAW09115.1
        		 344589 - 345815 (-) transcriptional factor
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          • ACLA_078650
          • EAW09116.1
          		 348127 - 350093 (-) cyclohexanone monooxygenase, putative
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            • ACLA_078660
            • EAW09117.1
            		 351008 - 363381 (-) hybrid NRPS/PKS enzyme, putative
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              • ACLA_078670
              • EAW09118.1
              		 365082 - 366679 (-) cytochrome P450 oxidoreductase GliF
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                • ACLA_078680
                • EAW09119.1
                		 367924 - 369304 (-) conserved hypothetical protein
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                  • ACLA_078690
                  • EAW09120.1
                  		 369641 - 370831 (-) conserved hypothetical protein
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                    • ACLA_078700
                    • EAW09121.1
                    		 371259 - 372412 (+) zinc-binding dehydrogenase family oxidoreductase, putative
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                      • ACLA_078710
                      • EAW09122.1
                      		 372611 - 374407 (+) cytochrome P450
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                        • ACLA_078720
                        • EAW09123.1
                        		 374885 - 375614 (+) thioredoxin, putative
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                          • ACLA_078730
                          • EAW09124.1
                          		 376973 - 378481 (+) mannitol dehydrogenase, putative
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            2
                            Type
                            nrps-type1
                            Genes
                            ACLA_078660
                            Substrates
                            phenylalanine (evidence: Structure-based inference [1])
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation
                            Name
                            1
                            Type
                            pks-modular
                            Genes
                            ACLA_078660
                            Substrates
                            Integrated Monomers
                            Domains
                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, methyltransferase
                            Annotation changelog

                            Entry version: next

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2024-06-04
                            MIBiG v4 annotathon
                            • (ID: 4B6CAZ6GBFQV2DK75DYGLHB6)
                            • (ID: D44UGPXERIZAXNCG2VXZP5I3)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Corrected NRP module activity
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Corrected gene identifiers
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Updated NRP substrate specificities
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2019-10-16
                            Updated compound(s) information (NPAtlas curation)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: BMUFDHMMOLZWQLUNJMQED2GP)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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