BGC0000984: delftibactin A biosynthetic gene cluster from Delftia acidovorans SPH-1
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Location: 5,200,652 - 5,260,767 nt. (total: 60,116 nt).
This entry is originally from NCBI GenBank CP000884.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000984
Short description delftibactin A biosynthetic gene cluster from Delftia acidovorans SPH-1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
CP000884.1
5200652 - 5260767
via
Compounds
  • delftibactin A
  • delftibactin B
Species Delftia acidovorans SPH-1 [taxonomy]
References
Chemical products information
delftibactin A Evidence:
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C40H68N14O18
Chemical database entries
NPAtlas
PubCHEM
delftibactin B Evidence:
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C41H70N14O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Daci_4745
  • ABX37374.1
 5200653 - 5201507 (-) conserved hypothetical protein
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    • Daci_4746
    • ABX37375.1
    		 5201529 - 5203244 (-) cyclic peptide transporter
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      • Daci_4747
      • ABX37376.1
      		 5203490 - 5204455 (+) Alpha/beta hydrolase fold-3 domain protein
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        • Daci_4748
        • ABX37377.1
        		 5204515 - 5205717 (+) conserved hypothetical protein
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          • Daci_4749
          • ABX37378.1
          		 5205729 - 5207027 (+) L-lysine 6-monooxygenase (NADPH)
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            • Daci_4750
            • ABX37379.1
            		 5207240 - 5207839 (+) RNA polymerase, sigma-24 subunit, ECF subfamily
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              • Daci_4751
              • ABX37380.1
              		 5207852 - 5208886 (+) anti-FecI sigma factor, FecR
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                • Daci_4752
                • ABX37381.1
                		 5208963 - 5211362 (-) TonB-dependent siderophore receptor
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                  • Daci_4753
                  • ABX37382.1
                  		 5211544 - 5230074 (-) amino acid adenylation domain protein
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                    • Daci_4754
                    • ABX37383.1
                    		 5230074 - 5240069 (-) amino acid adenylation domain protein
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                      • Daci_4755
                      • ABX37384.1
                      		 5240032 - 5244714 (-) Beta-ketoacyl synthase
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                        • Daci_4756
                        • ABX37385.1
                        		 5244714 - 5250083 (-) amino acid adenylation domain protein
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                          • Daci_4757
                          • ABX37386.1
                          		 5250104 - 5251093 (-) Taurine catabolism dioxygenase TauD/TfdA
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                            • Daci_4758
                            • ABX37387.1
                            		 5251090 - 5251779 (-) 4'-phosphopantetheinyl transferase
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                              • Daci_4759
                              • ABX37388.1
                              		 5251757 - 5252500 (-) Thioesterase
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                                • Daci_4760
                                • ABX37389.1
                                		 5252506 - 5252871 (-) MbtH domain protein
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                                  • Daci_4761
                                  • ABX37390.1
                                  		 5252942 - 5253466 (-) RNA polymerase, sigma-24 subunit, ECF subfamily
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                                    • Daci_4762
                                    • ABX37391.1
                                    		 5254614 - 5254949 (-) nitrogen regulatory protein P-II
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                                      • Daci_4763
                                      • ABX37392.1
                                      		 5254966 - 5258055 (-) heavy metal efflux pump, CzcA family
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                                        • Daci_4764
                                        • ABX37393.1
                                        		 5258060 - 5259277 (-) efflux transporter, RND family, MFP subunit
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                                          Biosynthesis information

                                          Biosynthetic modules

                                          Name
                                          Unk01
                                          Type
                                          nrps-type1
                                          Genes
                                          Daci_4753
                                          Substrates
                                          threonine (evidence: Structure-based inference, Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk02
                                          Type
                                          nrps-type1
                                          Genes
                                          Daci_4753
                                          Substrates
                                          ornithine (evidence: Structure-based inference, Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk03
                                          Type
                                          nrps-type1
                                          Genes
                                          Daci_4753
                                          Substrates
                                          serine (evidence: Structure-based inference, Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk04
                                          Type
                                          nrps-type1
                                          Genes
                                          Daci_4753
                                          Substrates
                                          arginine (evidence: Structure-based inference, Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk05
                                          Type
                                          nrps-type1
                                          Genes
                                          Daci_4753
                                          Substrates
                                          N5-hydroxyornithine (evidence: Structure-based inference, Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk06
                                          Type
                                          nrps-type1
                                          Genes
                                          Daci_4754
                                          Substrates
                                          aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk07
                                          Type
                                          nrps-type1
                                          Genes
                                          Daci_4754
                                          Substrates
                                          threonine (evidence: Structure-based inference, Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk08
                                          Type
                                          nrps-type1
                                          Genes
                                          Daci_4754
                                          Substrates
                                          glycine (evidence: Structure-based inference, Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk09
                                          Type
                                          nrps-type1
                                          Genes
                                          Daci_4756
                                          Substrates
                                          serine (evidence: Structure-based inference, Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Annotation changelog

                                          Entry version: next

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2024-08-10
                                          MIBiG v4 annotathon
                                          • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 3

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-09-15
                                          Linked new NPAtlas id for delftibactin A (npatlas:NPA020191)
                                          • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Refined reference coordinates
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Added NRP substrate specificities
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 2

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2019-10-16
                                          Migrated from v1.4
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 1

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2015-06-12
                                          Submitted
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          Detailed domain annotation
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