BGC0000985: didemnin B biosynthetic gene cluster from Tistrella mobilis KA081020-065
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Location: 674,941 - 729,697 nt. (total: 54,757 nt).
This entry is originally from NCBI GenBank CP003239.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000985
Short description didemnin B biosynthetic gene cluster from Tistrella mobilis KA081020-065
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Analysis of genes flanking didA-J, and within the Tistrella mobilis genome, did not reveal a discrete AT suggesting the Didemnin polyketide synthase may use the fatty acid synthase FabD"
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide (Other)
Loci NCBI GenBank: CP003239.1
Compounds
  • didemnin B
  • nordidemnin B
  • didemnin X
  • didemnin Y
Species Tistrella mobilis KA081020-065 [taxonomy]
References
Chemical products information
didemnin B
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C57H89N7O15
Chemical database entries
PubCHEM
nordidemnin B [synonyms: Nordidemnin, 117710-03-9, AC1L4U3F, AC1Q5K2N, 1-[(2s)-2-hydroxypropanoyl]-l-prolyl-n-[(3s,6r,7s,10r,11s,15s,17s,20s,25as)-11-hydroxy-3-(4-methoxybenzyl)-2,6,17-trimethyl-20-(2-methylpropyl)-1,4,8,13,16,18,21-heptaoxo-10,15-di(propan-2-yl)docosahydro-15h-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-yl]-n2-methylleucinamide, (2S)-N-[1-[[(3S,6S,8S,12S,13R,16S,17R,20S,23S)-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8,13-di(propan-2-yl)-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino]-4-methyl-1-oxopentan-2-yl]-1-[(2S)-2-hydroxypropanoyl]-N-methylpyrrolidine-2-carboxamide, Didemnin A, 1-(N-(1-(2-hydroxy-1-oxopropyl)-L-prolyl)-N-methyl-D-leucine)-3-((3S,4R)-3-hydroxy-5-methyl-4-aminohexanoic acid)-]
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C56H87N7O15
Chemical database entries
PubCHEM
didemnin X
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C82H130N12O24
Chemical database entries
PubCHEM
didemnin Y
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C87H138N14O26
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • TMO_c0602
  • AFK57212.1
  • didA
674941 - 681312 (+) DidA
  • Scaffold biosynthesis
Sequence-based prediction
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  • TMO_c0603
  • AFK57213.1
  • didB
681309 - 686699 (+) DidB
  • Scaffold biosynthesis
Sequence-based prediction
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  • TMO_c0604
  • AFK57214.1
  • didC
686696 - 690688 (+) DidC
  • Scaffold biosynthesis
Sequence-based prediction
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  • TMO_c0605
  • AFK57215.1
  • didD
690664 - 702225 (+) DidD
  • Scaffold biosynthesis
Sequence-based prediction
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  • TMO_c0606
  • AFK57216.1
  • didE
702250 - 707367 (+) DidE
  • Scaffold biosynthesis
Sequence-based prediction
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  • TMO_c0607
  • AFK57217.1
  • didF
707383 - 712224 (+) DidF
  • Scaffold biosynthesis
Sequence-based prediction
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  • TMO_c0608
  • AFK57218.1
  • didG
712221 - 716462 (+) DidG
  • Scaffold biosynthesis
Sequence-based prediction
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  • TMO_c0609
  • AFK57219.1
  • didH
716459 - 720319 (+) DidH
  • Scaffold biosynthesis
Sequence-based prediction
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  • TMO_c0610
  • AFK57220.1
  • didI
720291 - 722912 (+) DidI
  • Scaffold biosynthesis
Sequence-based prediction
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  • TMO_c0611
  • AFK57221.1
  • didJ
722909 - 729400 (+) DidJ
  • Scaffold biosynthesis
Sequence-based prediction
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  • TMO_c0612
  • AFK57222.1
  • mbtH
729464 - 729697 (+) MbtH domain-containing protein
  • Activation / processing
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Cyclic? yes
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactamization
Thioesterase genes
  • TMO_c0611 (Type I)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: FC27FLXW4TUBR6P2D2MHHJOO, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
Similar known gene clusters
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Detailed domain annotation
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