Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000985.1:
Cluster 1NRP / Polyketide154757

BGC0000985, didemnin biosynthetic gene cluster from Tistrella mobilis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Didemnin B
PubChem ID: 13895197
SMILES string: Copy to clipboard
Molecular formula: C57H89N7O15
Average molecular mass: 1112.373 Da
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Cyclic depsipeptide (cyclic)
Thioesterase type:
Type I
Release / cyclization type:
Macrolactamization

Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Trans-AT type I
Starter unit:
Other
Trans-acyltransferases in this cluster:

Gene cluster description

didemnin (BGC0000985). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank CP003239. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Jia Jia Zhang (University of California, San Diego)

Literature references

1. Xu Y et al. (2012) Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. J Am Chem Soc 134(20):8625-32. doi: 10.1021/ja301735a. Epub 2012 Apr