BGC0000992: fusaridione A biosynthetic gene cluster from Fusarium heterosporum
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Location: 1 - 60,504 nt. (total: 60,504 nt).
This entry is originally from NCBI GenBank AY700570.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
Genes
NRP
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000992
Short description fusaridione A biosynthetic gene cluster from Fusarium heterosporum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: AY700570.3
Compounds
  • fusaridione A
  • (3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione
Species Fusarium heterosporum [taxonomy]
References
Chemical products information
fusaridione A
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C27H31N1O4
Chemical database entries
PubCHEM
PubCHEM
(3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione
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C27H33N1O5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGO65982.1
  • gFH322
 668 - 3063 (-) putative multicopper oxidase
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  • AGO65983.1
  • gFH333
 4026 - 5939 (+) putative multicopper oxidase
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  • AAV66104.2
  • fsdR
 7974 - 9584 (-) putative fungal transcription factor
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  • AAV66105.2
  • gFH335
 10850 - 12987 (-) hypothetical protein
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  • AGO65984.1
  • gFH336
 13533 - 15211 (+) putative CoA-transferase-like protein
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  • AGO65985.1
  • gFH337
 15393 - 17174 (-) putative nucleoside phosphorylase-like protein
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  • AGO65986.1
  • gFH339
 19676 - 21919 (-) putative monooxygenase
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  • AGO65987.1
  • gFH340
 21245 - 23847 (+) putative metal-dependent hydrolase
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  • AAV66102.1
  • fsdK
 24673 - 26095 (-) putative dimethylallyltransferase
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  • AAV66107.2
  • fsdD
 26408 - 27370 (-) putative methyltransferase
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  • AGO65988.1
  • fsdH
 28230 - 30412 (+) putative cytochrome p450
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  • AGO65989.1
  • fsdG
 30795 - 32428 (+) putative MFS transporter
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  • AAV66110.2
  • fsdS
 33544 - 45616 (+) fusaridione A synthetase
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  • AGO65990.1
  • gFH438
 48948 - 50693 (+) hypothetical protein
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  • AGO65991.1
  • fsdC
 50751 - 51896 (-) putative enoylreductase-like protein
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  • AGO65992.1
  • gFH350
 52150 - 59922 (-) putative ankyrin-repeat containing protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
fsdS
Module ?
Specificity: tyrosine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for fusaridione A
  • Linked new PubChem id for fusaridione A (pubchem:91819845)
  • Add new compound: (3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione
  • Added NRP substrate specificities
Detailed domain annotation
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