BGC0000992: fusaridione A biosynthetic gene cluster from Fusarium heterosporum
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 60,504 nt. (total: 60,504 nt).
This entry is originally from NCBI GenBank AY700570.3.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000992
Short description fusaridione A biosynthetic gene cluster from Fusarium heterosporum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AY700570.3
via
Compounds
  • fusaridione A
  • (3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione
Species Fusarium heterosporum [taxonomy]
References
Chemical products information
fusaridione A Evidence:
Copy SMILES
C27H31N1O4
Chemical database entries
PubCHEM
PubCHEM
(3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione Evidence:
Copy SMILES
C27H33N1O5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGO65982.1
  • gFH322
 668 - 3063 (-) putative multicopper oxidase
    copy AA seq
    copy Nt seq
    • AGO65983.1
    • gFH333
    		 4026 - 5939 (+) putative multicopper oxidase
      copy AA seq
      copy Nt seq
      • AAV66104.2
      • fsdR
      		 7974 - 9584 (-) putative fungal transcription factor
        copy AA seq
        copy Nt seq
        • AAV66105.2
        • gFH335
        		 10850 - 12987 (-) hypothetical protein
          copy AA seq
          copy Nt seq
          • AGO65984.1
          • gFH336
          		 13533 - 15211 (+) putative CoA-transferase-like protein
            copy AA seq
            copy Nt seq
            • AGO65985.1
            • gFH337
            		 15393 - 17174 (-) putative nucleoside phosphorylase-like protein
              copy AA seq
              copy Nt seq
              • AGO65986.1
              • gFH339
              		 19676 - 21919 (-) putative monooxygenase
                copy AA seq
                copy Nt seq
                • AGO65987.1
                • gFH340
                		 21245 - 23847 (+) putative metal-dependent hydrolase
                  copy AA seq
                  copy Nt seq
                  • AAV66102.1
                  • fsdK
                  		 24673 - 26095 (-) putative dimethylallyltransferase
                    copy AA seq
                    copy Nt seq
                    • AAV66107.2
                    • fsdD
                    		 26408 - 27370 (-) putative methyltransferase
                      copy AA seq
                      copy Nt seq
                      • AGO65988.1
                      • fsdH
                      		 28230 - 30412 (+) putative cytochrome p450
                        copy AA seq
                        copy Nt seq
                        • AGO65989.1
                        • fsdG
                        		 30795 - 32428 (+) putative MFS transporter
                          copy AA seq
                          copy Nt seq
                          • AAV66110.2
                          • fsdS
                          		 33544 - 45616 (+) fusaridione A synthetase
                            copy AA seq
                            copy Nt seq
                            • AGO65990.1
                            • gFH438
                            		 48948 - 50693 (+) hypothetical protein
                              copy AA seq
                              copy Nt seq
                              • AGO65991.1
                              • fsdC
                              		 50751 - 51896 (-) putative enoylreductase-like protein
                                copy AA seq
                                copy Nt seq
                                • AGO65992.1
                                • gFH350
                                		 52150 - 59922 (-) putative ankyrin-repeat containing protein
                                  copy AA seq
                                  copy Nt seq
                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  fsdS
                                  Substrates
                                  tyrosine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Update compound structure (SMILES) for fusaridione A
                                  • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Linked new PubChem id for fusaridione A (pubchem:91819845)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Add new compound: (3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2015-06-12
                                  Submitted
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  Detailed domain annotation
                                  Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                  A domain glossary is available here, and an explanation of the visualisation is available here.
                                  Selected features only
                                  Show module domains
                                  Similar known gene clusters from MIBiG 4.0
                                  Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                  Click on reference genes to show details of similarities to genes within the current region.
                                  Click on an accession to open that entry in the MiBIG database.