BGC0000993 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000993 (Chromobacterium violaceum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	40,434	FR901228	NRPS:Type I+PKS:Type I	100%

BGC0000993 - Region 1 - NRPS

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Location: 1 - 40,434 nt. (total: 40,434 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 40,435
Label		BGC0000993

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000993	1.00	NRP, Polyketide	FR901228	Chromobacterium violaceum
BGC0000426	0.37	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.37	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0000016	0.35	Other	amphotericin B	Streptomyces nodosus
BGC0002071	0.33	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000457	0.31	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001023	0.31	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0001671	0.30	NRP	monobactam	Agrobacterium tumefaciens
BGC0000964	0.29	NRP, Polyketide	burkholdac A, burkholdac B	Burkholderia thailandensis E264
BGC0002437	0.29	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000993	1.00	NRP, Polyketide	FR901228	Chromobacterium violaceum
BGC0000426	0.70	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.69	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0000016	0.68	Other	amphotericin B	Streptomyces nodosus
BGC0002071	0.66	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000457	0.64	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001023	0.64	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0001671	0.64	NRP	monobactam	Agrobacterium tumefaciens
BGC0000964	0.63	NRP, Polyketide	burkholdac A, burkholdac B	Burkholderia thailandensis E264
BGC0002437	0.63	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 40434:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys) + (D-Val - D-Cys) + (Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

depA

Search NORINE for peptide: strict or relaxed

CAL_domain (60..484): pk

minowa: Acetyl-CoA

Prediction, score:

Acetyl-CoA: 47.7
AHBA: 11.9
NH2: 5.1
shikimic_acid: 3.6
fatty_acid: 0.0

AMP-binding (1105..1489): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

depD

Search NORINE for peptide: strict or relaxed

AMP-binding (524..917): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWLGGTFK
Nearest Stachelhaus code(s):: Val DAFWLGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2022..2416): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFEMSLIWK
Nearest Stachelhaus code(s):: Cys DLFEMSLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

depE

Search NORINE for peptide: strict or relaxed

AMP-binding (482..884): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWSFGLVHK
Nearest Stachelhaus code(s):: Thr DFWSFGLVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)