BGC0000993: FR901228 biosynthetic gene cluster from Chromobacterium violaceum
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Location: 1 - 40,434 nt. (total: 40,434 nt).
This entry is originally from NCBI GenBank EF210776.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000993
Short description FR901228 biosynthetic gene cluster from Chromobacterium violaceum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
EF210776.1
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • FR901228
Species Chromobacterium violaceum [taxonomy]
References
Chemical products information
FR901228 Evidence:
Copy SMILES
C24H36N4O6S2
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABP57738.1
 2 - 454 (+) 16S rRNA pseudouridine synthase
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    • ABP57739.1
    		 466 - 957 (+) MutT/nudix family phosphohydrolase
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      • ABP57740.1
      		 972 - 1544 (+) transcription elongation factor GreB
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        • ABP57741.1
        • depK
        		 1616 - 1873 (-) DepK
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          • ABP57742.1
          • depL
          		 1971 - 2438 (-) DepL
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            • ABP57743.1
            • depM
            		 2513 - 3682 (+) DepM
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              • ABP57744.1
              • depN
              		 4469 - 4666 (+) DepN
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                • ABP57745.1
                • depA
                		 5034 - 10127 (+) DepA
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                  • ABP57746.1
                  • depB
                  		 10127 - 14788 (+) DepB
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                    • ABP57747.1
                    • depC
                    		 14785 - 18336 (+) DepC
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                      • ABP57748.1
                      • depD
                      		 18333 - 27506 (+) DepD
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                        • ABP57749.1
                        • depE
                        		 27503 - 33181 (+) DepE
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                          • ABP57750.1
                          • depF
                          		 33178 - 34350 (+) DepF
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                            • ABP57751.1
                            • depG
                            		 34347 - 35312 (+) DepG
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                              • ABP57752.1
                              • depH
                              		 35309 - 36268 (+) DepH
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                                • ABP57753.1
                                • depI
                                		 36324 - 37238 (+) DepI
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                                  • ABP57754.1
                                  • depJ
                                  		 37235 - 37999 (+) DepJ
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                                    • ABP57755.1
                                    		 38068 - 39006 (-) hydrogen peroxid-inducible genes activator OxyR
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                                      • ABP57756.1
                                      		 39010 - 39267 (-) cell division topological specificity factor MinE
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                                        • ABP57757.1
                                        		 39271 - 40083 (-) septum site-determining protein MinD
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                                          • ABP57758.1
                                          		 40110 - >40433 (-) septum formation inhibitor MinC
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                                            Biosynthesis information

                                            Biosynthetic modules

                                            Name
                                            Unk01
                                            Type
                                            nrps-type1
                                            Genes
                                            depA
                                            Substrates
                                            cysteine (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk02
                                            Type
                                            nrps-type1
                                            Genes
                                            depD
                                            Substrates
                                            valine (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk03
                                            Type
                                            nrps-type1
                                            Genes
                                            depD
                                            Substrates
                                            cysteine (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk04
                                            Type
                                            nrps-type1
                                            Genes
                                            depE
                                            Substrates
                                            threonine (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Annotation changelog

                                            Entry version: 3

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Corrected gene identifiers
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Added NRP substrate specificities
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2019-10-16
                                            Migrated from v1.4
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2019-10-16
                                            Updated compound(s) information (NPAtlas curation)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2015-06-12
                                            Submitted
                                            • (ID: DUUOEWRWRZA5NTLPQCYGT6Z6)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            Detailed domain annotation
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