BGC0000994: FR-900520 biosynthetic gene cluster from Streptomyces hygroscopicus subsp. ascomyceticus
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Location: 1 - 77,534 nt. (total: 77,534 nt).
This entry is originally from NCBI GenBank AF235504.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000994
Short description FR-900520 biosynthetic gene cluster from Streptomyces hygroscopicus subsp. ascomyceticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AF235504.1
via
Compounds
  • FR-900520
Species Streptomyces hygroscopicus subsp. ascomyceticus [taxonomy]
References
Chemical products information
FR-900520 Evidence:
Copy SMILES
C43H69N1O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAF86380.1
  • fkbW
 412 - 1836 (-) FkbW
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    • AAF86381.1
    • fkbU
    		 2020 - 3579 (-) polyhydroxybutyrate depolymerase
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      • AAF86382.1
      • fkbR2
      		 3969 - 4496 (-) FkbR2
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        • AAF86383.1
        • fkbR1
        		 4595 - 5488 (-) FkbR1
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          • AAF86384.1
          • fkbE
          		 5601 - 6818 (+) FkbE
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            • AAF86385.1
            • fkbF
            		 6808 - 8052 (+) FkbF
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              • AAF86386.1
              • fkbG
              		 8156 - 8824 (+) FkbG
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                • AAF86387.1
                • fkbH
                		 8802 - 9884 (-) FkbH
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                  • AAF86388.1
                  • fkbI
                  		 9895 - 10995 (-) FkbI
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                    • AAF86389.1
                    • fkbJ
                    		 10988 - 11248 (-) FkbJ
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                      • AAF86390.1
                      • fkbK
                      		 11245 - 12093 (-) FkbK
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                        • AAF86391.1
                        • fkbL
                        		 12114 - 13151 (-) FkbL
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                          • AAF86392.1
                          • fkbC
                          		 13214 - 23989 (-) FkbC
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                            • AAF86393.1
                            • fkbB
                            		 23994 - 46571 (-) FkbB
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                              • AAF86394.1
                              • fkbO
                              		 46752 - 47786 (+) FkbO
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                                • AAF86395.1
                                • fkbP
                                		 47783 - 52270 (+) FkbP
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                                  • AAF86396.1
                                  • fkbA
                                  		 52273 - 71463 (+) FkbA
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                                    • AAF86397.1
                                    • fkbD
                                    		 71460 - 72626 (+) FkbD
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                                      • AAF86398.1
                                      • fkbM
                                      		 72623 - 73405 (+) FkbM
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                                        • AAF86399.1
                                        • fkbN
                                        		 73459 - 76200 (-) FkbN
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                                          • AAF86400.1
                                          • fkbQ
                                          		 76335 - 77078 (-) FkbQ
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                                            • AAF86401.1
                                            • fkbS
                                            		 77075 - >77533 (-) FkbS
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                                              Biosynthesis information

                                              Biosynthetic modules

                                              Name
                                              Unk01
                                              Type
                                              nrps-type1
                                              Genes
                                              fkbP
                                              Substrates
                                              pipecolic acid (evidence: )
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Annotation changelog

                                              Entry version: 4

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-10-07
                                              Update chemical activity to schema version 2.11
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 3

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-09-15
                                              Updated bioactivity data
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2022-09-15
                                              Added NRP substrate specificities
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 2

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2019-10-16
                                              Migrated from v1.4
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2019-10-16
                                              Updated compound(s) information (NPAtlas curation)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2015-06-12
                                              Submitted
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              Detailed domain annotation
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