Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000996.1:
Cluster 1NRP / Polyketide116575

BGC0000996, frontalamides biosynthetic gene cluster from Streptomyces sp. SPB78. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: frontalamide B
SMILES string: Copy to clipboard
Molecular formula: C29H36N2O6
Exact molecular mass: 509.2662 Da ([M+H]+)
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (cyclic)
Thioesterase type:
Type I
Release / cyclization type:

Nonribosomal peptide synthetases:
Module 1
A specificity: Ornithine
Evidence for specificity: Structure-based inference
C domain subtype: Unknown
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Iterative typeI
Starter unit:
Polyketide synthase / ketosynthase-encoding genes:
Iterative PKS subtype:
Partially reducing
Number of iterations:
Thioesterase type:
Release / cyclization type:

Modular polyketide synthases:
Module 12
AT specificity: Malonyl-CoA
Evidence for specificity: Unknown
KR stereochemistry: Unknown
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

frontalamides (BGC0000996). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank GG657742, positions 4892742-4909316. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?incomplete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
Comments:The ftdB gene is present in three parts, and must be merged. A new paper includes the publication of a fragment that closed a genome sequencing gap within FtdB. Locus tags and protein ID comprising FtdB from N-C terminus: SSLG_04251, protein_id=ADJ54381.1,SSLG_04252. This is why there are two loci listed, which is technically incorrect. Only one locus but in GenBank as the sum of two accession numbers.
Contact for this cluster:Joshua Blodgett (Washington Univeristy in St Louis)

Literature references

1. Blodgett JA et al. (2010) Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria. Proc Natl Acad Sci U S A 107(26):11692-7. doi: