BGC0001000: hectochlorin biosynthetic gene cluster from Lyngbya majuscula
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Location: 1 - 41,964 nt. (total: 41,964 nt).
This entry is originally from NCBI GenBank AY974560.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001000
Short description hectochlorin biosynthetic gene cluster from Lyngbya majuscula
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "The phylogeny/classification of the producing organism for this molecule has been updated from Lyngbya majuscula JHB to Moorea producens JHB. "
Biosynthetic class(es)
  • NRP (Other lipopeptide)
  • Polyketide (Other)
Loci NCBI GenBank: AY974560.1
Compounds
  • hectochlorin
Species Lyngbya majuscula [taxonomy]
References
Chemical products information
hectochlorin
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C27H34Cl2N2O9S2
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAY42393.1
 2444 - 4264 (+) Acyl-ACP synthetase
  • Precursor biosynthesis
Sequence-based prediction
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  • AAY42394.1
 5267 - 6721 (+) Putative halogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • AAY42395.1
 6964 - 8190 (+) Putative transposase
  • Unknown
Sequence-based prediction
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  • AAY42396.1
 8248 - 14022 (+) Polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAY42397.1
 14019 - 24089 (+) Nonribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAY42398.1
 24086 - 35923 (+) Nonribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAY42399.1
 36589 - 37932 (+) Cytochrome P450 monooxygenase
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • AAY42400.1
 38547 - 39881 (+) Cytochrome P450 monooxygenase
  • Tailoring (Hydroxylation)
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Cyclic? yes
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
AAY42396.1 Synthase subclass: Modular type I
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAY42396.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
NRP-specific information
Subclass Other lipopeptide
Cyclic? yes
Release type
  • Hydrolysis
Thioesterase genes
  • AAY42398.1 (Type I)
NRP-synthases
Gene Modules
AAY42393.1
Module 0
Condensation domain type: Starter
AAY42397.1
Module 2
Specificity: 2-ketoisovaleric acid
Evidence for specificity:
  • Activity assay
Condensation domain type: LCL
Module 3
Specificity: cysteine
Evidence for specificity:
  • Activity assay
Condensation domain type: Heterocyclization
Modification domains: Oxidation
AAY42398.1
Module 4
Specificity: 2-ketoisovaleric acid
Evidence for specificity:
  • Activity assay
Condensation domain type: LCL
Module 5
Specificity: cysteine
Evidence for specificity:
  • Activity assay
Condensation domain type: Heterocyclization
Modification domains: Oxidation
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AFDKNJ3M7IY2EN7OLH4KRCAV, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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