Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001001.1:
Cluster 1NRP / Polyketide169900

BGC0001001, jamaicamide biosynthetic gene cluster from Lyngbya majuscula. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Jamaicamide
PubChem ID: 49787031
SMILES string: Copy to clipboard
Molecular formula: C27H36BrClN2O4
Average molecular mass: 567.949 Da
Molecular activity: Other
Molecular target: Sodium channel blocking

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (cyclic)
Thioesterase type:
None
Release / cyclization type:
None

Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Other
Thioesterase type:
Unknown
Release / cyclization type:
Macrolactamization

Gene cluster description

Download cluster GenBank file
jamaicamide (BGC0001001). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank AY522504, positions 6630-63646. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Daniel Edwards (California State University, Chico)

Literature references

1. Esquenazi E et al. (2011) Temporal dynamics of natural product biosynthesis in marine cyanobacteria. Proc Natl Acad Sci U S A 108(13):5226-31. doi:
2. Jones AC et al. (2009) Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins. BMC Microbiol 9:247. doi: 10.1186/1471-2180-9-247.
3. Gu L et al. (2009) Metamorphic enzyme assembly in polyketide diversification. Nature 459(7247):731-5. doi: 10.1038/nature07870.
4. Dorrestein PC et al. (2006) Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry 45(6):1537-46. doi: 10.1021/bi052333k.