BGC0001001: jamaicamide A biosynthetic gene cluster from Lyngbya majuscula
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Location: 1 - 69,900 nt. (total: 69,900 nt).
This entry is originally from NCBI GenBank AY522504.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001001
Short description jamaicamide A biosynthetic gene cluster from Lyngbya majuscula
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AY522504.1
Compounds
  • jamaicamide A
  • jamaicamide B
  • jamaicamide C
Species Lyngbya majuscula [taxonomy]
References
Chemical products information
jamaicamide A
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C27H36Br1Cl1N2O4
Chemical database entries
NPAtlas
jamaicamide B
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C27H37Cl1N2O4
Chemical database entries
NPAtlas
PubCHEM
jamaicamide C
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C27H39Cl1N2O4
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAS98794.1
 1 - 2415 (+) sucrose synthase
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  • AAS98795.1
 2460 - 2813 (-) hypothetical protein
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  • AAS98796.1
 3126 - 3749 (-) putative transposase
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  • AAS98797.1
 4382 - 4957 (-) transposase
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  • AAS98774.1
 6630 - 8408 (+) Acyl-ACP Synthetase
  • Activation / processing
Activity assay
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  • AAS98775.1
 8591 - 9556 (+) Desaturase
  • Precursor biosynthesis
Sequence-based prediction
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  • AAS98798.1
 9718 - 10020 (+) acyl carrier protein
  • Activation / processing
Activity assay
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  • AAS98776.1
 10463 - 12514 (+) Putative bromination enzyme
  • Tailoring (Halogenation)
Sequence-based prediction
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  • AAS98777.1
 12596 - 17788 (+) polyketide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAS98799.1
 17811 - 18050 (+) acyl carrier protein
  • Activation / processing
Sequence-based prediction
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  • AAS98778.1
 18222 - 19448 (+) ketosynthase/decarboxylase
  • Tailoring (Decarboxylation)
Sequence-based prediction
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  • AAS98779.1
 19453 - 20712 (+) hydroxymethyl glutaryl-ACP synthase like activity
  • Tailoring (Unknown)
Sequence-based prediction
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  • AAS98780.1
 20982 - 21746 (+) enoyl hydratase family
  • Tailoring (Dehydration)
Activity assay
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  • AAS98781.1
 21734 - 31642 (+) polyketide synthase
  • Scaffold biosynthesis
Activity assay
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  • AAS98782.1
 31659 - 36752 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAS98783.1
 36820 - 48627 (+) polyketide synthase/nonribosomal peptide synthase hybrid
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAS98784.1
 48697 - 51696 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAS98785.1
 51811 - 53277 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAS98786.1
 53274 - 56750 (+) nonribosomal peptide synthetase
  • Scaffold biosynthesis
Activity assay
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  • AAS98787.1
 56771 - 62197 (+) polyketide synthase/thioesterase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAS98788.1
 62318 - 63646 (-) cyclization enzyme
  • Tailoring (Heterocyclization)
Sequence-based prediction
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  • AAS98789.1
 64050 - 64766 (-) hypothetical protein
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  • AAS98790.1
 64894 - 65517 (-) putative transposase
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  • AAS98792.1
 66175 - 66621 (-) hypothetical protein
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  • AAS98791.1
 67688 - 68833 (-) choloylglycine hydrolase-like protein
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  • AAS98793.1
 68839 - 69279 (-) hypothetical protein
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Polyketide-specific information
Subclass Other
Cyclic? yes
Release type
  • Macrolactamization
NRP-specific information
Subclass N/A
Cyclic? yes
NRP-synthases
Gene Modules
AAS98786.1
Module ?
Specificity: alanine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 5P6FUCFK6SYJZTN7O5IL377F, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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