BGC0001002 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001002 (Streptomyces roseoverticillatus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	13,261	jawsamycin	NRPS:Type I+PKS	100%

BGC0001002 - Region 1 - T1PKS

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Location: 1 - 13,261 nt. (total: 13,261 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 13,262
Label		BGC0001002

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001002	1.00	NRP, Polyketide	jawsamycin	Streptomyces roseoverticillatus
BGC0002138	0.37	Polyketide	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670
BGC0000867	0.26	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000866	0.26	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001197	0.24	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000860	0.22	Other	ectoine	Methylarcula marina
BGC0000231	0.21	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000204	0.21	Polyketide	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0002474	0.21	NRP	agrobactin	Agrobacterium tumefaciens
BGC0000888	0.21	Other	bacilysin	Bacillus sp. CS93

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001002	1.00	NRP, Polyketide	jawsamycin	Streptomyces roseoverticillatus
BGC0002138	0.69	Polyketide	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670
BGC0000867	0.60	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000866	0.59	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001197	0.57	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000860	0.55	Other	ectoine	Methylarcula marina
BGC0000231	0.54	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000204	0.54	Polyketide	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0002474	0.54	NRP	agrobactin	Agrobacterium tumefaciens
BGC0000888	0.53	Other	bacilysin	Bacillus sp. CS93

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 13261:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

jaw4

PKS_AT (568..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 167.7
inactive: 99.8
Methoxymalonyl-CoA: 96.1
Methylmalonyl-CoA: 85.6
Propionyl-CoA: 56.8
Isobutyryl-CoA: 41.6
Ethylmalonyl-CoA: 40.2
2-Methylbutyryl-CoA: 37.4
fatty_acid: 34.9
CHC-CoA: 30.0
Acetyl-CoA: 29.8
Benzoyl-CoA: 20.1
trans-1,2-CPDA: 17.8
3-Methylbutyryl-CoA: 17.6