BGC0001003: α-lipomycin biosynthetic gene cluster from Kitasatospora aureofaciens
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Location: 1 - 66,871 nt. (total: 66,871 nt).
This entry is originally from NCBI GenBank DQ176871.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001003
Short description α-lipomycin biosynthetic gene cluster from Kitasatospora aureofaciens
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Other lipopeptide)
  • Polyketide (Polyene)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: DQ176871.1
Compounds
  • α-lipomycin
Species Kitasatospora aureofaciens [taxonomy]
References
Chemical products information
α-lipomycin
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C32H45N1O9
Chemical database entries
PubCHEM
ChEBI
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABB05090.1
  • lipReg1
 1 - 675 (-) LipReg1
  • Regulation
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  • ABB05091.1
  • lipReg2
 760 - 2019 (-) LipReg2
  • Regulation
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  • ABB05092.1
  • lipX1
 2569 - 2958 (+) LipX1
  • Regulation
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  • ABB05093.1
  • lipEx1
 3180 - 5480 (-) LipEx1
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  • ABB05094.1
  • lipReg3
 5477 - 5947 (-) negative regulator
  • Regulation
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  • ABB05095.1
  • lipReg4
 6203 - 8713 (+) LipReg4
  • Regulation
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  • ABB05096.1
  • lipGtf
 9167 - 10399 (-) LipGtf
  • Tailoring (Glycosylation)
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  • ABB05097.1
  • lipDig1
 10415 - 11284 (-) LipDig1
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  • ABB05098.1
  • lipDig2
 11305 - 12273 (-) LipDig2
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  • ABB05099.1
  • lipMt
 12641 - 13666 (+) LipMt
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  • ABB05100.1
  • lipX2
 13678 - 14511 (+) LipX2
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  • ABB05101.1
  • lipNrps
 14608 - 16851 (+) LipNrps
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  • ABB05102.1
  • lipPks1
 16927 - 23706 (+) LipPks1
  • Scaffold biosynthesis
Activity assay
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  • ABB05103.1
  • lipPks2
 23820 - 34568 (+) LipPks2
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  • ABB05104.1
  • lipPks3
 34627 - 45465 (+) LipPks3
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  • ABB05105.1
  • lipPks4
 45491 - 55324 (+) LipPks4
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  • ABB05106.1
  • lipTe
 55363 - 56112 (+) LipTe
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  • ABB05107.1
  • lipX3
 57097 - 61779 (-) LipX3
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  • ABB05108.1
  • lipX4
 61941 - 63125 (-) LipX4
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  • ABB05109.1
  • lipDig3
 63320 - 64303 (-) LipDig3
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  • ABB05110.1
  • lipDig4
 64347 - 65414 (-) LipDig4
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  • ABB05111.1
  • lipDig5
 65411 - 66871 (-) LipDig5
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Polyketide-specific information
Subclass Polyene
Starter unit Isobutyryl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
lipPks3
+
lipPks4
+
lipPks1
+
lipPks2 		Synthase subclass: Modular type I
Module 0
Specificity: Isobutyryl-CoA
Evidence for specificity: Activity assay
Genes: lipPks1
Core domains: Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lipPks1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lipPks2
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Malonyl-CoA
Genes: lipPks2
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Genes: lipPks3
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Malonyl-CoA
Genes: lipPks3
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Specificity: Malonyl-CoA
Genes: lipPks4
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Specificity: Malonyl-CoA
Genes: lipPks4
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass Other lipopeptide
Cyclic? no
Lipid moiety pentaen chain
NRP-synthases
Gene Modules
lipNrps
Module 1
Specificity: glutamic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Saccharide-specific information
Subclass hybrid/tailoring
Sugar-encoding genes
  • lipDig1, lipDig2, lipDig3, lipDig4, lipDig5
Glycosyltransferases
lipGtf
Specificity: L-digitoxose
Evidence:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: LPHAMZXQ3BT6INJWOLKUYGWU, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Linked new PubChem id for α-lipomycin (pubchem:54723870)
  • Update structure (SMILES) for α-lipomycin
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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