BGC0001003: α-lipomycin biosynthetic gene cluster from Kitasatospora aureofaciens
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 66,871 nt. (total: 66,871 nt).
This entry is originally from NCBI GenBank DQ176871.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001003
Short description α-lipomycin biosynthetic gene cluster from Kitasatospora aureofaciens
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
  • saccharide (hybrid/tailoring)
Loci
DQ176871.1
via Knock-out studies
Compounds
  • α-lipomycin
Species Kitasatospora aureofaciens [taxonomy]
References
Chemical products information
α-lipomycin Evidence:
Copy SMILES
C32H45N1O9
Chemical database entries
PubCHEM
ChEBI
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABB05090.1
  • lipReg1
 1 - 675 (-) LipReg1
  • Regulation
  • Knock-out Other in vivo study
copy AA seq
copy Nt seq
  • ABB05091.1
  • lipReg2
 760 - 2019 (-) LipReg2
  • Regulation
  • Knock-out Other in vivo study
copy AA seq
copy Nt seq
  • ABB05092.1
  • lipX1
 2569 - 2958 (+) LipX1
  • Regulation
  • Knock-out Other in vivo study
copy AA seq
copy Nt seq
  • ABB05093.1
  • lipEx1
 3180 - 5480 (-) LipEx1
    copy AA seq
    copy Nt seq
    • ABB05094.1
    • lipReg3
    		 5477 - 5947 (-) negative regulator
    • Regulation
    • Knock-out Other in vivo study
    copy AA seq
    copy Nt seq
    • ABB05095.1
    • lipReg4
    		 6203 - 8713 (+) LipReg4
    • Regulation
    • Knock-out Other in vivo study
    copy AA seq
    copy Nt seq
    • ABB05096.1
    • lipGtf
    		 9167 - 10399 (-) LipGtf
    • Tailoring
    • Knock-out
    copy AA seq
    copy Nt seq
    • ABB05097.1
    • lipDig1
    		 10415 - 11284 (-) LipDig1
      copy AA seq
      copy Nt seq
      • ABB05098.1
      • lipDig2
      		 11305 - 12273 (-) LipDig2
        copy AA seq
        copy Nt seq
        • ABB05099.1
        • lipMt
        		 12641 - 13666 (+) LipMt
          copy AA seq
          copy Nt seq
          • ABB05100.1
          • lipX2
          		 13678 - 14511 (+) LipX2
            copy AA seq
            copy Nt seq
            • ABB05101.1
            • lipNrps
            		 14608 - 16851 (+) LipNrps
              copy AA seq
              copy Nt seq
              • ABB05102.1
              • lipPks1
              		 16927 - 23706 (+) LipPks1
              • Scaffold biosynthesis
              • Activity assay
              copy AA seq
              copy Nt seq
              • ABB05103.1
              • lipPks2
              		 23820 - 34568 (+) LipPks2
                copy AA seq
                copy Nt seq
                • ABB05104.1
                • lipPks3
                		 34627 - 45465 (+) LipPks3
                  copy AA seq
                  copy Nt seq
                  • ABB05105.1
                  • lipPks4
                  		 45491 - 55324 (+) LipPks4
                    copy AA seq
                    copy Nt seq
                    • ABB05106.1
                    • lipTe
                    		 55363 - 56112 (+) LipTe
                      copy AA seq
                      copy Nt seq
                      • ABB05107.1
                      • lipX3
                      		 57097 - 61779 (-) LipX3
                        copy AA seq
                        copy Nt seq
                        • ABB05108.1
                        • lipX4
                        		 61941 - 63125 (-) LipX4
                          copy AA seq
                          copy Nt seq
                          • ABB05109.1
                          • lipDig3
                          		 63320 - 64303 (-) LipDig3
                            copy AA seq
                            copy Nt seq
                            • ABB05110.1
                            • lipDig4
                            		 64347 - 65414 (-) LipDig4
                              copy AA seq
                              copy Nt seq
                              • ABB05111.1
                              • lipDig5
                              		 65411 - 66871 (-) LipDig5
                                copy AA seq
                                copy Nt seq
                                Biosynthesis information

                                Biosynthetic modules

                                Name
                                1
                                Type
                                nrps-type1
                                Genes
                                lipNrps
                                Substrates
                                glutamic acid (evidence: Structure-based inference)
                                Integrated Monomers
                                Domains
                                condensation, adenylation
                                Name
                                0
                                Type
                                pks-modular-starter
                                Genes
                                lipPks1
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, carrier (ACP)
                                Name
                                1
                                Type
                                pks-modular
                                Genes
                                lipPks1
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                Name
                                2
                                Type
                                pks-modular
                                Genes
                                lipPks2
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                Name
                                3
                                Type
                                pks-modular
                                Genes
                                lipPks2
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                Name
                                4
                                Type
                                pks-modular
                                Genes
                                lipPks3
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                Name
                                5
                                Type
                                pks-modular
                                Genes
                                lipPks3
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                Name
                                6
                                Type
                                pks-modular
                                Genes
                                lipPks4
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                Name
                                7
                                Type
                                pks-modular
                                Genes
                                lipPks4
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                Annotation changelog

                                Entry version: 4

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-10-07
                                Update chemical activity to schema version 2.11
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Linked new PubChem id for α-lipomycin (pubchem:54723870)
                                • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Update structure (SMILES) for α-lipomycin
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Corrected NRP module activity
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Changed amino acid substrates to lower case
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2015-06-12
                                Submitted
                                • (ID: LPHAMZXQ3BT6INJWOLKUYGWU)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                Detailed domain annotation
                                Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                A domain glossary is available here, and an explanation of the visualisation is available here.
                                Selected features only
                                Show module domains
                                Similar known gene clusters from MIBiG 4.0
                                Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                Click on reference genes to show details of similarities to genes within the current region.
                                Click on an accession to open that entry in the MiBIG database.