BGC0001004: lobophorin B biosynthetic gene cluster from Streptomyces sp. SCSIO 01127
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Location: 2,344 - 100,910 nt. (total: 98,567 nt).
This entry is originally from NCBI GenBank KC013978.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001004
Short description lobophorin B biosynthetic gene cluster from Streptomyces sp. SCSIO 01127
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The cluster described is found within Streptomyces sp. SCSIO 01127"
Biosynthetic class(es)
  • PKS (Type I)
Loci
KC013978.1
2344 - 100910
via Knock-out studies, Enzymatic assays
Compounds
  • lobophorin B
Species Streptomyces sp. SCSIO 01127 [taxonomy]
References
Chemical products information
lobophorin B Evidence:
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C61H90N2O21
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGI99474.1
  • lobR1
 2344 - 2931 (+) TetR type regulatory protein
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    • AGI99475.1
    • lobT1
    		 2956 - 4449 (-) efflux permease
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      • AGI99476.1
      • lobP1
      		 4655 - 5833 (+) p450 monooxygenase
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        • AGI99477.1
        • lobU1
        		 5977 - 6957 (+) aldo/keto reductase
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          • AGI99478.1
          • lobS1
          		 7103 - 7918 (+) sugar-O-methyltransferase
          • Tailoring
          • Knock-out Activity assay
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          • AGI99479.1
          • lobS2
          		 8028 - 9182 (-) sugar 4-aminotransferase
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            • AGI99480.1
            • lobS3
            		 9380 - 10180 (+) SAM-dependent methyltransferase
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              • AGI99481.1
              • lobG1
              		 10227 - 11402 (+) glycosyltransferase
              • Tailoring
              • Knock-out
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              • AGI99482.1
              • lobA1
              		 11697 - 23507 (-) Type I polyketide synthase
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                • AGI99483.1
                • lobS4
                		 23770 - 25221 (+) sugar 2,3-dehydratase
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                  • AGI99484.1
                  • lobB
                  		 25227 - 25988 (+) thioesterase
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                    • AGI99485.1
                    • lobP2
                    		 26077 - 27597 (+) FAD-dependent oxidoreductase
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                      • AGI99486.1
                      • lobG2
                      		 27667 - 28917 (-) glycosyltransferase
                      • Tailoring
                      • Knock-out
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                      • AGI99487.1
                      • lobG3
                      		 28960 - 30162 (-) glycosyltransferase
                      • Tailoring
                      • Knock-out
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                      • AGI99488.1
                      • lobR2
                      		 30254 - 30871 (+) TetR type regulatory protein
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                        • AGI99489.1
                        • lobC1
                        		 30896 - 32746 (-) hydrolase superfamily dihydrolipo- amide acyltransferase-like protein
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                          • AGI99490.1
                          • lobC2
                          		 32743 - 32970 (-) ACP
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                            • AGI99491.1
                            • lobC3
                            		 32967 - 34832 (-) FkbH-like protein
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                              • AGI99492.1
                              • lobC4
                              		 34829 - 35857 (-) ketoacyl acylcarrier protein synthase III
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                                • AGI99493.1
                                • lobP3
                                		 35927 - 37405 (-) FAD-dependent oxidoreductase
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                                  • AGI99494.1
                                  • lobA2
                                  		 37515 - 42236 (-) Type I polyketide synthase
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                                    • AGI99495.1
                                    • lobA3
                                    		 42264 - 47660 (-) Type I polyketide synthase
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                                      • AGI99496.1
                                      • lobA4
                                      		 47687 - 69142 (-) Type I polyketide synthase
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                                        • AGI99497.1
                                        • lobA5
                                        		 69169 - 88230 (-) type I polyketide synthase
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                                          • AGI99498.1
                                          • lonU2
                                          		 88339 - 88794 (-) unknown
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                                            • AGI99499.1
                                            • lobS5
                                            		 88870 - 90114 (-) sugar 3-C-methyl transferase
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                                              • AGI99500.1
                                              • lobS6
                                              		 90188 - 91309 (-) sugar 3-aminotransferase
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                                                • AGI99501.1
                                                • lobS7
                                                		 91315 - 92634 (-) FAD-dependent oxidoreductase
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                                                  • AGI99502.1
                                                  • lobS8
                                                  		 92722 - 93747 (-) sugar 4,6-dehydratase
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                                                    • AGI99503.1
                                                    • lobS9
                                                    		 93734 - 94630 (-) sugar nucleotidyltransferase
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                                                      • AGI99504.1
                                                      • lobS10
                                                      		 95189 - 96187 (-) sugar 3-ketoreductase
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                                                        • AGI99505.1
                                                        • lobS11
                                                        		 96276 - 96884 (-) sugar 5-epimerase
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                                                          • AGI99506.1
                                                          • lobR3
                                                          		 96970 - 97794 (-) TetR type regulatory protein
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                                                            • AGI99507.1
                                                            • lobT2
                                                            		 97791 - 98426 (-) Forkhead-associated protein
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                                                              • AGI99508.1
                                                              • lobR4
                                                              		 98657 - 99553 (-) putative regulatory protein
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                                                                • AGI99509.1
                                                                • lobR5
                                                                		 99981 - 100910 (-) LysR family transcriptional regulator
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                                                                  Biosynthesis information

                                                                  Biosynthetic modules

                                                                  Name
                                                                  0
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA5
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                                  Name
                                                                  1
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA5
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                  Name
                                                                  2
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA5
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  3
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA5
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  4
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA4
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  5
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA4
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  6
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA4
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  7
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA4
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                  Name
                                                                  8
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA3
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  9
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA1
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                                                                  Name
                                                                  10
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA1
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  11
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA2
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                  Annotation changelog

                                                                  Entry version: 4

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-10-07
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 3

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-09-15
                                                                  Corrected polyketide synthase gene entries
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-09-15
                                                                  Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-09-15
                                                                  Sorted modules by module number
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2019-10-16
                                                                  Migrated from v1.4
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2019-10-16
                                                                  Updated compound(s) information (NPAtlas curation)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2015-06-12
                                                                  Submitted
                                                                  • (ID: YU43TGF6RSKW2WJOQIFYBQO4)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Detailed domain annotation
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