BGC0001004: lobophorin B biosynthetic gene cluster from Streptomyces sp. SCSIO 01127
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 2,344 - 100,910 nt. (total: 98,567 nt).
This entry is originally from NCBI GenBank KC013978.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001004
Short description lobophorin B biosynthetic gene cluster from Streptomyces sp. SCSIO 01127
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The cluster described is found within Streptomyces sp. SCSIO 01127"
Biosynthetic class(es)
  • PKS (Type I)
Loci
KC013978.1
2344 - 100910
via Knock-out studies, Enzymatic assays
Compounds
  • lobophorin B
Species Streptomyces sp. SCSIO 01127 [taxonomy]
References
Chemical products information
lobophorin B Evidence:
Copy SMILES
C61H90N2O21
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGI99474.1
  • lobR1
2344 - 2931 (+) TetR type regulatory protein
    copy AA seq
    copy Nt seq
    • AGI99475.1
    • lobT1
    2956 - 4449 (-) efflux permease
      copy AA seq
      copy Nt seq
      • AGI99476.1
      • lobP1
      4655 - 5833 (+) p450 monooxygenase
        copy AA seq
        copy Nt seq
        • AGI99477.1
        • lobU1
        5977 - 6957 (+) aldo/keto reductase
          copy AA seq
          copy Nt seq
          • AGI99478.1
          • lobS1
          7103 - 7918 (+) sugar-O-methyltransferase
          • Tailoring
          • Knock-out Activity assay
          copy AA seq
          copy Nt seq
          • AGI99479.1
          • lobS2
          8028 - 9182 (-) sugar 4-aminotransferase
            copy AA seq
            copy Nt seq
            • AGI99480.1
            • lobS3
            9380 - 10180 (+) SAM-dependent methyltransferase
              copy AA seq
              copy Nt seq
              • AGI99481.1
              • lobG1
              10227 - 11402 (+) glycosyltransferase
              • Tailoring
              • Knock-out
              copy AA seq
              copy Nt seq
              • AGI99482.1
              • lobA1
              11697 - 23507 (-) Type I polyketide synthase
                copy AA seq
                copy Nt seq
                • AGI99483.1
                • lobS4
                23770 - 25221 (+) sugar 2,3-dehydratase
                  copy AA seq
                  copy Nt seq
                  • AGI99484.1
                  • lobB
                  25227 - 25988 (+) thioesterase
                    copy AA seq
                    copy Nt seq
                    • AGI99485.1
                    • lobP2
                    26077 - 27597 (+) FAD-dependent oxidoreductase
                      copy AA seq
                      copy Nt seq
                      • AGI99486.1
                      • lobG2
                      27667 - 28917 (-) glycosyltransferase
                      • Tailoring
                      • Knock-out
                      copy AA seq
                      copy Nt seq
                      • AGI99487.1
                      • lobG3
                      28960 - 30162 (-) glycosyltransferase
                      • Tailoring
                      • Knock-out
                      copy AA seq
                      copy Nt seq
                      • AGI99488.1
                      • lobR2
                      30254 - 30871 (+) TetR type regulatory protein
                        copy AA seq
                        copy Nt seq
                        • AGI99489.1
                        • lobC1
                        30896 - 32746 (-) hydrolase superfamily dihydrolipo- amide acyltransferase-like protein
                          copy AA seq
                          copy Nt seq
                          • AGI99490.1
                          • lobC2
                          32743 - 32970 (-) ACP
                            copy AA seq
                            copy Nt seq
                            • AGI99491.1
                            • lobC3
                            32967 - 34832 (-) FkbH-like protein
                              copy AA seq
                              copy Nt seq
                              • AGI99492.1
                              • lobC4
                              34829 - 35857 (-) ketoacyl acylcarrier protein synthase III
                                copy AA seq
                                copy Nt seq
                                • AGI99493.1
                                • lobP3
                                35927 - 37405 (-) FAD-dependent oxidoreductase
                                  copy AA seq
                                  copy Nt seq
                                  • AGI99494.1
                                  • lobA2
                                  37515 - 42236 (-) Type I polyketide synthase
                                    copy AA seq
                                    copy Nt seq
                                    • AGI99495.1
                                    • lobA3
                                    42264 - 47660 (-) Type I polyketide synthase
                                      copy AA seq
                                      copy Nt seq
                                      • AGI99496.1
                                      • lobA4
                                      47687 - 69142 (-) Type I polyketide synthase
                                        copy AA seq
                                        copy Nt seq
                                        • AGI99497.1
                                        • lobA5
                                        69169 - 88230 (-) type I polyketide synthase
                                          copy AA seq
                                          copy Nt seq
                                          • AGI99498.1
                                          • lonU2
                                          88339 - 88794 (-) unknown
                                            copy AA seq
                                            copy Nt seq
                                            • AGI99499.1
                                            • lobS5
                                            88870 - 90114 (-) sugar 3-C-methyl transferase
                                              copy AA seq
                                              copy Nt seq
                                              • AGI99500.1
                                              • lobS6
                                              90188 - 91309 (-) sugar 3-aminotransferase
                                                copy AA seq
                                                copy Nt seq
                                                • AGI99501.1
                                                • lobS7
                                                91315 - 92634 (-) FAD-dependent oxidoreductase
                                                  copy AA seq
                                                  copy Nt seq
                                                  • AGI99502.1
                                                  • lobS8
                                                  92722 - 93747 (-) sugar 4,6-dehydratase
                                                    copy AA seq
                                                    copy Nt seq
                                                    • AGI99503.1
                                                    • lobS9
                                                    93734 - 94630 (-) sugar nucleotidyltransferase
                                                      copy AA seq
                                                      copy Nt seq
                                                      • AGI99504.1
                                                      • lobS10
                                                      95189 - 96187 (-) sugar 3-ketoreductase
                                                        copy AA seq
                                                        copy Nt seq
                                                        • AGI99505.1
                                                        • lobS11
                                                        96276 - 96884 (-) sugar 5-epimerase
                                                          copy AA seq
                                                          copy Nt seq
                                                          • AGI99506.1
                                                          • lobR3
                                                          96970 - 97794 (-) TetR type regulatory protein
                                                            copy AA seq
                                                            copy Nt seq
                                                            • AGI99507.1
                                                            • lobT2
                                                            97791 - 98426 (-) Forkhead-associated protein
                                                              copy AA seq
                                                              copy Nt seq
                                                              • AGI99508.1
                                                              • lobR4
                                                              98657 - 99553 (-) putative regulatory protein
                                                                copy AA seq
                                                                copy Nt seq
                                                                • AGI99509.1
                                                                • lobR5
                                                                99981 - 100910 (-) LysR family transcriptional regulator
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  Biosynthesis information

                                                                  Biosynthetic modules

                                                                  Name
                                                                  0
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA5
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                                  Name
                                                                  1
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA5
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                  Name
                                                                  2
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA5
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  3
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA5
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  4
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA4
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  5
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA4
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  6
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA4
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  7
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA4
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                  Name
                                                                  8
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA3
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  9
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA1
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                                                                  Name
                                                                  10
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA1
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  11
                                                                  Type
                                                                  pks-modular
                                                                  Genes
                                                                  lobA2
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                  Annotation changelog

                                                                  Entry version: 4

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 3

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  Corrected polyketide synthase gene entries
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Sorted modules by module number
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  Migrated from v1.4
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Updated compound(s) information (NPAtlas curation)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  Submitted
                                                                  • (ID: YU43TGF6RSKW2WJOQIFYBQO4)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Detailed domain annotation
                                                                  Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                  A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                  Selected features only
                                                                  Show module domains
                                                                  Similar known gene clusters from MIBiG 4.0
                                                                  Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                  Click on reference genes to show details of similarities to genes within the current region.
                                                                  Click on an accession to open that entry in the MiBIG database.