BGC0001004: lobophorin B biosynthetic gene cluster from Streptomyces sp. SCSIO 01127
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Location: 2,344 - 100,910 nt. (total: 98,567 nt).
This entry is originally from NCBI GenBank KC013978.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0001004
Short description lobophorin B biosynthetic gene cluster from Streptomyces sp. SCSIO 01127
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "The cluster described is found within Streptomyces sp. SCSIO 01127"
Biosynthetic class(es)
  • Polyketide (Macrolide)
Loci NCBI GenBank: KC013978.1
Compounds
  • lobophorin B
Species Streptomyces sp. SCSIO 01127 [taxonomy]
References
Chemical products information
lobophorin B
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C61H90N2O21
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGI99474.1
  • lobR1
 2344 - 2931 (+) TetR type regulatory protein
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  • AGI99475.1
  • lobT1
 2956 - 4449 (-) efflux permease
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  • AGI99476.1
  • lobP1
 4655 - 5833 (+) p450 monooxygenase
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  • AGI99477.1
  • lobU1
 5977 - 6957 (+) aldo/keto reductase
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  • AGI99478.1
  • lobS1
 7103 - 7918 (+) sugar-O-methyltransferase
  • Tailoring (Methylation)
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  • AGI99479.1
  • lobS2
 8028 - 9182 (-) sugar 4-aminotransferase
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  • AGI99480.1
  • lobS3
 9380 - 10180 (+) SAM-dependent methyltransferase
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  • AGI99481.1
  • lobG1
 10227 - 11402 (+) glycosyltransferase
  • Tailoring (Glycosylation)
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  • AGI99482.1
  • lobA1
 11697 - 23507 (-) Type I polyketide synthase
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  • AGI99483.1
  • lobS4
 23770 - 25221 (+) sugar 2,3-dehydratase
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  • AGI99484.1
  • lobB
 25227 - 25988 (+) thioesterase
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  • AGI99485.1
  • lobP2
 26077 - 27597 (+) FAD-dependent oxidoreductase
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  • AGI99486.1
  • lobG2
 27667 - 28917 (-) glycosyltransferase
  • Tailoring (Glycosylation)
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  • AGI99487.1
  • lobG3
 28960 - 30162 (-) glycosyltransferase
  • Tailoring (Glycosylation)
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  • AGI99488.1
  • lobR2
 30254 - 30871 (+) TetR type regulatory protein
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  • AGI99489.1
  • lobC1
 30896 - 32746 (-) hydrolase superfamily dihydrolipo- amide acyltransferase-like protein
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  • AGI99490.1
  • lobC2
 32743 - 32970 (-) ACP
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  • AGI99491.1
  • lobC3
 32967 - 34832 (-) FkbH-like protein
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  • AGI99492.1
  • lobC4
 34829 - 35857 (-) ketoacyl acylcarrier protein synthase III
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  • AGI99493.1
  • lobP3
 35927 - 37405 (-) FAD-dependent oxidoreductase
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  • AGI99494.1
  • lobA2
 37515 - 42236 (-) Type I polyketide synthase
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  • AGI99495.1
  • lobA3
 42264 - 47660 (-) Type I polyketide synthase
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  • AGI99496.1
  • lobA4
 47687 - 69142 (-) Type I polyketide synthase
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  • AGI99497.1
  • lobA5
 69169 - 88230 (-) type I polyketide synthase
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  • AGI99498.1
  • lonU2
 88339 - 88794 (-) unknown
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  • AGI99499.1
  • lobS5
 88870 - 90114 (-) sugar 3-C-methyl transferase
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  • AGI99500.1
  • lobS6
 90188 - 91309 (-) sugar 3-aminotransferase
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  • AGI99501.1
  • lobS7
 91315 - 92634 (-) FAD-dependent oxidoreductase
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  • AGI99502.1
  • lobS8
 92722 - 93747 (-) sugar 4,6-dehydratase
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  • AGI99503.1
  • lobS9
 93734 - 94630 (-) sugar nucleotidyltransferase
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  • AGI99504.1
  • lobS10
 95189 - 96187 (-) sugar 3-ketoreductase
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  • AGI99505.1
  • lobS11
 96276 - 96884 (-) sugar 5-epimerase
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  • AGI99506.1
  • lobR3
 96970 - 97794 (-) TetR type regulatory protein
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  • AGI99507.1
  • lobT2
 97791 - 98426 (-) Forkhead-associated protein
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  • AGI99508.1
  • lobR4
 98657 - 99553 (-) putative regulatory protein
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  • AGI99509.1
  • lobR5
 99981 - 100910 (-) LysR family transcriptional regulator
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Polyketide-specific information
Subclass Macrolide
Starter unit Malonyl-CoA
Cyclic? yes
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
lobA3
+
lobA1
+
lobA2
+
lobA5
+
lobA4 		Synthase subclass: Modular type I
Module 0
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lobA5
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Methylmalonyl-CoA
Genes: lobA5
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Malonyl-CoA
Genes: lobA5
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Methylmalonyl-CoA
Genes: lobA5
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lobA4
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lobA4
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Specificity: Malonyl-CoA
Genes: lobA4
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Specificity: Malonyl-CoA
Genes: lobA4
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 8
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lobA3
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 9
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lobA1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 10
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lobA1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 11
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lobA2
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: YU43TGF6RSKW2WJOQIFYBQO4, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected polyketide synthase gene entries
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Sorted modules by module number
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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