Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001004.1:
Cluster 1Polyketide198567

BGC0001004, lobophorin biosynthetic gene cluster from Streptomyces sp. SCSIO. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: lobophorin B
PubChem ID: 44566672
SMILES string: Copy to clipboard
Molecular formula: C22H32O4
Average molecular mass: 360.494 Da
Molecular activity: Antibacterial, Cytotoxic

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Malonyl-CoA
Thioesterase type:
Unknown
Release / cyclization type:
Hydrolysis

Modular polyketide synthases:
lobA1, AGI99482.1
Module 10
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Module 9
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown

lobA2, AGI99494.1
Module 11
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference

lobA3, AGI99495.1
Module 8
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference

lobA4, AGI99496.1
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Module 5
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Module 6
AT specificity: Malonyl-CoA
Evidence for specificity: Unknown
Module 7
AT specificity: Malonyl-CoA
Evidence for specificity: Unknown

lobA5
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown
Module 0
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Unknown
Module 3
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown

Gene cluster description

lobophorin (BGC0001004). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KC013978, positions 2344-100910. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays
MIxS-compliance:Unknown
Comments:The cluster described is found within Streptomyces sp. SCSIO 01127
Contact for this cluster:Changsheng Zhang (South China Sea Institute of Oceanology, Chinese Academy of Sciences)

Literature references

1. Xiao J et al. (2013) Characterization of the sugar-O-methyltransferase LobS1 in lobophorin biosynthesis. Appl Microbiol Biotechnol 97(20):9043-53. doi:
2. Li S et al. (2013) Dissecting glycosylation steps in lobophorin biosynthesis implies an iterative glycosyltransferase. Org Lett 15(6):1374-7. doi: 10.1021/ol400342e. Epub 2013 Feb 22.
3. Niu S et al. (2011) Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127. J Antibiot (Tokyo) 64(11):711-6. doi: 10.1038/ja.2011.78. Epub 2011 Sep