BGC0001005: locillomycin biosynthetic gene cluster from Bacillus subtilis
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 46,783 nt. (total: 46,783 nt).
This entry is originally from NCBI GenBank KF866134.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001005
Short description locillomycin biosynthetic gene cluster from Bacillus subtilis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
KF866134.1
via
Compounds
  • locillomycin
  • locillomycin B
  • locillomycin C
Species Bacillus subtilis [taxonomy]
References
Chemical products information
locillomycin Evidence:
Copy SMILES
C52H79N11O18
locillomycin B Evidence:
Copy SMILES
C53H81N11O18
locillomycin C Evidence:
Copy SMILES
C54H83N11O18
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHI59103.1
  • ybbR
 1 - 1440 (+) YbbR-like domain-containing protein
    copy AA seq
    copy Nt seq
    • AHI59104.1
    • glmM
    		 1437 - 2804 (+) phosphoglucosamine mutase
      copy AA seq
      copy Nt seq
      • AHI59105.1
      • glmS
      		 3236 - 5038 (+) L-glutamine-D-fructose-6-phosphate amidotransferase
        copy AA seq
        copy Nt seq
        • AHI59106.1
        • potA
        		 5675 - 6550 (+) putative ATP binding protein of ABC transporter
          copy AA seq
          copy Nt seq
          • AHI59107.1
          • locD
          		 7565 - 11446 (+) locillomycin synthase D
            copy AA seq
            copy Nt seq
            • AHI59108.1
            • locA
            		 11667 - 18644 (+) locillomycin synthase A
              copy AA seq
              copy Nt seq
              • AHI59109.1
              • locB
              		 18726 - 30332 (+) locillomycin synthase B
                copy AA seq
                copy Nt seq
                • AHI59110.1
                • locC
                		 30402 - 36782 (+) locillomycin synthase C
                  copy AA seq
                  copy Nt seq
                  • AHI59111.1
                  • graR
                  		 36883 - 37566 (+) response regulator protein GraR
                    copy AA seq
                    copy Nt seq
                    • AHI59112.1
                    		 37563 - 38585 (+) two-component sensor histidine kinase
                      copy AA seq
                      copy Nt seq
                      • AHI59113.1
                      • potB
                      		 39787 - 40551 (+) ATPase
                        copy AA seq
                        copy Nt seq
                        • AHI59114.1
                        • potC
                        		 40538 - 42466 (+) permease
                          copy AA seq
                          copy Nt seq
                          • AHI59115.1
                          • potD
                          		 42518 - 45550 (+) multidrug transporter
                            copy AA seq
                            copy Nt seq
                            • AHI59116.1
                            • kdgR1
                            		 45938 - 46783 (-) putative 2,5-diketo-D-gluconic acid reductase
                              copy AA seq
                              copy Nt seq
                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              locA
                              Substrates
                              threonine (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk02
                              Type
                              nrps-type1
                              Genes
                              locB
                              Substrates
                              glutamine, aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk03
                              Type
                              nrps-type1
                              Genes
                              locB
                              Substrates
                              aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk04
                              Type
                              nrps-type1
                              Genes
                              locB
                              Substrates
                              glycine (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk05
                              Type
                              nrps-type1
                              Genes
                              locC
                              Substrates
                              tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk06
                              Type
                              nrps-type1
                              Genes
                              locC
                              Substrates
                              valine (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Add new compound structure (SMILES) for locillomycin
                              • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Add new compound: locillomycin B
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Add new compound: locillomycin C
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2019-10-16
                              Updated reference publication(s) (MIBiG Annotathon)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-06-12
                              Submitted
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
                              Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                              A domain glossary is available here, and an explanation of the visualisation is available here.
                              Selected features only
                              Show module domains
                              Similar known gene clusters from MIBiG 4.0
                              Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                              Click on reference genes to show details of similarities to genes within the current region.
                              Click on an accession to open that entry in the MiBIG database.