BGC0001005: locillomycin biosynthetic gene cluster from Bacillus subtilis
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Location: 1 - 46,783 nt. (total: 46,783 nt).
This entry is originally from NCBI GenBank KF866134.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001005
Short description locillomycin biosynthetic gene cluster from Bacillus subtilis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: KF866134.1
Compounds
  • locillomycin
  • locillomycin B
  • locillomycin C
Species Bacillus subtilis [taxonomy]
References
Chemical products information
locillomycin
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C52H79N11O18
locillomycin B
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C53H81N11O18
locillomycin C
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C54H83N11O18
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHI59103.1
  • ybbR
 1 - 1440 (+) YbbR-like domain-containing protein
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  • AHI59104.1
  • glmM
 1437 - 2804 (+) phosphoglucosamine mutase
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  • AHI59105.1
  • glmS
 3236 - 5038 (+) L-glutamine-D-fructose-6-phosphate amidotransferase
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  • AHI59106.1
  • potA
 5675 - 6550 (+) putative ATP binding protein of ABC transporter
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  • AHI59107.1
  • locD
 7565 - 11446 (+) locillomycin synthase D
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  • AHI59108.1
  • locA
 11667 - 18644 (+) locillomycin synthase A
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  • AHI59109.1
  • locB
 18726 - 30332 (+) locillomycin synthase B
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  • AHI59110.1
  • locC
 30402 - 36782 (+) locillomycin synthase C
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  • AHI59111.1
  • graR
 36883 - 37566 (+) response regulator protein GraR
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  • AHI59112.1
 37563 - 38585 (+) two-component sensor histidine kinase
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  • AHI59113.1
  • potB
 39787 - 40551 (+) ATPase
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  • AHI59114.1
  • potC
 40538 - 42466 (+) permease
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  • AHI59115.1
  • potD
 42518 - 45550 (+) multidrug transporter
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  • AHI59116.1
  • kdgR1
 45938 - 46783 (-) putative 2,5-diketo-D-gluconic acid reductase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
locA
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
locB
Module ?
Specificity: glutamine / aspartic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
locC
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Add new compound structure (SMILES) for locillomycin
  • Add new compound: locillomycin B
  • Add new compound: locillomycin C
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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