BGC0001006: lymphostin biosynthetic gene cluster from Salinispora tropica CNB-440
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Location: 3,494,094 - 3,519,138 nt. (total: 25,045 nt).
This entry is originally from NCBI GenBank CP000667.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001006
Short description lymphostin biosynthetic gene cluster from Salinispora tropica CNB-440
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: CP000667.1
Compounds
  • lymphostin
  • neolymphostinol B
  • lymphostinol
  • neolymphostin B
Species Salinispora tropica CNB-440 [taxonomy]
References
Chemical products information
lymphostin
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C16H14N4O3
Chemical database entries
NPAtlas
neolymphostinol B
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C16H16N4O3
Chemical database entries
NPAtlas
lymphostinol
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C15H14N4O3
Chemical database entries
NPAtlas
neolymphostin B
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C17H16N4O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Strop_3055
  • ABP55492.1
 3494094 - 3494951 (+) Methyltransferase type 11
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  • Strop_3056
  • ABP55493.1
 3495062 - 3502192 (+) thioester reductase domain
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  • Strop_3057
  • ABP55494.1
 3502319 - 3504280 (-) asparagine synthase (glutamine-hydrolysing)
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  • Strop_3058
  • ABP55495.1
 3504401 - 3505879 (+) Xaa-Pro aminopeptidase
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  • Strop_3059
  • ABP55496.1
 3506161 - 3507732 (+) hypothetical protein
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  • Strop_3060
  • ABP55497.1
 3508078 - 3510099 (+) hypothetical protein
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  • Strop_3061
  • ABP55498.1
 3510166 - 3513006 (-) alpha-1,6-glucosidase, pullulanase-type
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  • Strop_3062
  • ABP55499.1
 3513294 - 3516128 (+) aconitase
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  • Strop_3063
  • ABP55500.1
 3516255 - 3516536 (+) hypothetical protein
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  • Strop_3064
  • ABP55501.1
 3516645 - 3517571 (-) protein of unknown function RIO1
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  • Strop_3065
  • ABP55502.1
 3517727 - 3518371 (-) HAD-superfamily hydrolase, subfamily IA, variant 1
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  • Strop_3066
  • ABP55503.1
 3518566 - 3519138 (+) transcriptional regulator, TetR family
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
Strop_3056 Synthase subclass:
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: Strop_3056
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Reductive release
NRP-synthases
Gene Modules
Strop_3056
Module 0
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: UJYWT4SZRXDY2IOPYAIF6MII, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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