Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001006.1:
Cluster 1NRP / Polyketide125045

BGC0001006, lymphostin biosynthetic gene cluster from Salinispora tropica. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: lymphostin
SMILES string: Copy to clipboard
Molecular formula: C16H14N4O3
Exact molecular mass: 310.3074 Da ([M+H]+)
Molecular activity: Inhibitor
Molecular target: mTOR

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Reductive release

Nonribosomal peptide synthetases:
ABP55493.1
Module 0
A specificity: None
Evidence for specificity: Structure-based inference
C domain subtype: N/A

Modular polyketide synthases:
ABP55493.1
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None

Gene cluster description

lymphostin (BGC0001006). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank CP000667, positions 3474953-3505751. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Bradley S Moore (Scripps Institution of Oceanography)

Literature references

1. Udwary DW et al. (2007) Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc Natl Acad Sci U S A 104(25):10376-81. doi:
2. Miyanaga A et al. (2011) Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria. J Am Chem Soc 133(34):13311-3. doi: 10.1021/ja205655w. Epub 2011 Aug