Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001007.1:
Cluster 1Polyketide / NRP123687

BGC0001007, lymphostin biosynthetic gene cluster from Salinispora arenicola. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: lymphostin
SMILES string: Copy to clipboard
Molecular formula: C16H14N4O3
Exact molecular mass: 310.3074 Da ([M+H]+)
Molecular activity: Inhibitor
Molecular target: mTOR

Class-specific details

Biosynthetic class(es):
Polyketide / NRP
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Reductive release

Nonribosomal peptide synthetases:
ABV99085.1
Module 0
A specificity: None
Evidence for specificity: Structure-based inference
C domain subtype: N/A

Modular polyketide synthases:
ABV99085.1
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None

Gene cluster description

lymphostin (BGC0001007). Gene Cluster 1. Biosynthetic class = Polyketide/NRP. GenBank CP000850, positions 3762400-3793643. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Bradley S Moore (Scripps Institution of Oceanography)

Literature references

1. Penn K et al. (2009) Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. ISME J 3(10):1193-203. doi: 10.1038/ismej.2009.58. Epub 2009 May 28.
2. Miyanaga A et al. (2011) Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria. J Am Chem Soc 133(34):13311-3. doi: 10.1021/ja205655w. Epub 2011 Aug