BGC0001010: melithiazol A biosynthetic gene cluster from Melittangium lichenicola
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Location: 1 - 51,855 nt. (total: 51,855 nt).
This entry is originally from NCBI GenBank AJ557546.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001010
Short description melithiazol A biosynthetic gene cluster from Melittangium lichenicola
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AJ557546.1
Compounds
  • melithiazol A
Species Melittangium lichenicola [taxonomy]
References
Chemical products information
melithiazol A
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C20H26N2O4S2
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAD89764.1
 1 - 253 (-) hypothetical protein
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  • CAD89765.1
 442 - 1488 (-) hypothetical protein
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  • CAD89766.1
 3093 - 4529 (-) hypothetical protein
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  • CAD89767.1
 6939 - 8291 (+) hypothetical protein
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  • CAD89768.1
 8857 - 9420 (+) hypothetical protein
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  • CAD89769.1
 10009 - 10707 (+) hypothetical protein
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  • CAD89770.1
 10704 - 12062 (+) hypothetical protein
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  • CAD89771.1
 12120 - 13082 (+) hypothetical protein
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  • CAD89772.1
 13098 - 13454 (-) hypothetical protein
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  • CAD89773.1
  • melB
 13880 - 17032 (+) MelB protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAD89774.1
  • melC
 17065 - 21036 (+) MelC protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAD89775.1
  • melD
 21033 - 30887 (+) MelD protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAD89776.1
  • melE
 30940 - 36678 (+) MelE protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAD89777.1
  • melF
 36675 - 40757 (+) MelF protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAD89778.1
  • melG
 40757 - 46000 (+) MelG protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAD89779.1
  • melH
 46019 - 47008 (+) MelH protein
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  • CAD89780.1
  • melJ
 47014 - 48021 (-) MelJ protein
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  • CAD89781.1
  • melK
 48018 - 48923 (-) MelK protein
  • Tailoring (Methylation)
Heterologous expression
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  • CAD89782.1
 50068 - 51855 (+) hypothetical protein
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Polyketide-specific information
Subclass Other
Starter unit Isobutyryl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
melF
+
melB
+
melD
+
melE 		Synthase subclass: Modular type I
Module 1
Specificity: Isobutyryl-CoA
Evidence for specificity: Structure-based inference
Genes: melB
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: melD
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 5
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: melE
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 6
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: melF
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
melC
Module 2
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
Modification domains: Oxidation
melD
Module 3
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
Modification domains: Oxidation
melG
Module 7
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Remove leading/trailing whitespace in gene identifiers
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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