Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001010.1:
Cluster 1NRP / Polyketide151855

BGC0001010, melithiazol biosynthetic gene cluster from Melittangium lichenicola. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Melithiazol A
SMILES string: Copy to clipboard
Molecular formula: C20H26N2O4S2
Exact molecular mass: 423.1407 Da ([M+H]+)
Molecular activity: Antifungal, Cytotoxic
Molecular target: respiratory chain inhibitor BC-I complex

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
Type I
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
melC (CAD89774.1)
Module 2
A specificity: Cysteine
Evidence for specificity: Structure-based inference
C domain subtype: Heterocyclization
Scaffold-modifying domain: Oxidation
melD (CAD89775.1)
Module 3
A specificity: Cysteine
Evidence for specificity: Structure-based inference
C domain subtype: Heterocyclization
Scaffold-modifying domain: Oxidation
melG (CAD89778.1)
Module 7
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Isobutyryl-CoA
Thioesterase type:
None
Release / cyclization type:
Other

Modular polyketide synthases:
melB (CAD89773.1)
Module 1
AT specificity: Isobutyryl-CoA
Evidence for specificity: Structure-based inference

melD (CAD89775.1)
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group

melE (CAD89776.1)
Module 5
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group

melF (CAD89777.1)
Module 6
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference

Gene cluster description

melithiazol (BGC0001010). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank AJ557546, positions 1-51855. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Weinig S et al. (2003) Melithiazol biosynthesis: further insights into myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases. Chem Biol 10(10):939-52.