BGC0001011: meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748
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Location: 1 - 116,831 nt. (total: 116,831 nt).
This entry is originally from NCBI GenBank DQ351275.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001011
Short description meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: DQ351275.1
Compounds
  • meridamycin
Species Streptomyces sp. NRRL 30748 [taxonomy]
References
Chemical products information
meridamycin
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C45H75N1O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABC87493.1
 196 - 1083 (-) purine synthase
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  • ABC87494.1
 1240 - 2805 (-) purine synthase
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  • ABC87495.1
 2802 - 3458 (-) purine synthase
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  • ABC87496.1
 3860 - 4702 (+) ion transport protein
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  • ABC87497.1
 4765 - 6618 (-) membrane protein
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  • ABC87498.1
 6853 - 7737 (-) succinyl-CoA synthetase alpha chain
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  • ABC87499.1
 7759 - 8877 (-) succinyl-CoA synthetase beta chain
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  • ABC87500.1
 9295 - 10935 (+) beta-1,4-endo glucanase
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  • ABC87501.1
 11012 - 12352 (-) argininosuccinate synthase
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  • ABC87502.1
 12652 - 14784 (-) mycodextranase
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  • ABC87503.1
 14894 - 16492 (-) alpha-1, 4-glucosidase
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  • ABC87504.1
 16523 - 17398 (-) sugar transporter intracellular portion
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  • ABC87505.1
 17395 - 18417 (-) sugar transporter intracellular portion
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  • ABC87506.1
 18356 - 19786 (-) sugar transporter extracellular portion
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  • ABC87507.1
 19917 - 20915 (-) LacI family transcription regulator
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  • ABC87508.1
  • merP
 21568 - 26286 (+) NRPS for pipecolate incorporation
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  • ABC87509.1
  • merA
 26259 - 43397 (+) polyketide synthase
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  • ABC87510.1
  • merB
 43455 - 64763 (+) polyketide synthase
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  • ABC87511.1
  • merC
 64760 - 88666 (+) polyketide synthase
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  • ABC87512.1
  • merD
 88050 - 98327 (+) polyketide synthase
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  • ABC87513.1
  • merE
 98368 - 99561 (+) cytochrome P450 monooxygenase
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  • ABC87514.1
  • merF-1
 99711 - 100367 (-) unknown
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  • ABC87515.1
  • merF-2
 100253 - 100789 (-) unknown
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  • ABC87516.1
  • merG
 101189 - 102673 (-) drug efflux transporter
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  • ABC87517.1
  • merH
 102792 - 103271 (-) drug resistance related regulator
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  • ABC87518.1
  • merI
 103353 - 104297 (-) regulatory protein
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  • ABC87519.1
  • merJ
 104252 - 105247 (+) membrane protein
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  • ABC87520.1
  • merK
 105357 - 106181 (-) unknown
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  • ABC87521.1
  • merL
 106294 - 107343 (-) unknown
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  • ABC87522.1
  • merM
 107413 - 107820 (-) resistance related regulator
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  • ABC87523.1
  • merN
 107905 - 109398 (-) putative drug efflux transporter
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  • ABC87524.1
  • merO
 109395 - 110036 (-) drug resistance related regulator
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  • ABC87525.1
  • merQ
 110126 - 111172 (-) LysR family regulator
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  • ABC87526.1
  • merR
 111037 - 111693 (+) unknown
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  • ABC87527.1
  • merS
 111822 - 113201 (+) FAD-dependent monooxygenase
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  • ABC87528.1
  • merT
 113251 - 113658 (-) unknown
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  • ABC87529.1
  • merU
 113891 - 116341 (-) unknown
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  • ABC87530.1
  • merV
 116429 - >116831 (+) methyl transferase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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