BGC0001011 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001011 (Streptomyces sp. NRRL 30748)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	116,831	meridamycin	NRPS:Type I+PKS	100%

BGC0001011 - Region 1 - NRPS,T1PKS

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Location: 1 - 116,831 nt. (total: 116,831 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 116,832
Label		BGC0001011

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001011	1.37	NRP, Polyketide	meridamycin	Streptomyces sp. NRRL 30748
BGC0001012	0.74	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0002285	0.66	RiPP	aborycin	Streptomyces sp. ZS0098
BGC0000996	0.64	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0000457	0.64	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000417	0.57	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000342	0.55	NRP	enniatin	Fusarium equiseti
BGC0000313	0.55	NRP	beauvericin	Beauveria bassiana
BGC0000122	0.54	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0002171	0.54	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger ATCC 1015

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001011	1.00	NRP, Polyketide	meridamycin	Streptomyces sp. NRRL 30748
BGC0001012	0.81	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0002285	0.69	RiPP	aborycin	Streptomyces sp. ZS0098
BGC0001013	0.68	NRP, Polyketide	meridamycin	Streptomyces sp.
BGC0000844	0.68	Other	clavulanic acid	Streptomyces clavuligerus
BGC0000996	0.67	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0000457	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000067	0.65	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000122	0.64	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 1567 - 116831:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Hpr) + (mal - pk - Me-ccmal - ohmal) + (pk - pk - pk - pk) + (ohmal - ohmal - pk - ohmal - ohmal) + (pk - ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

merP

Search NORINE for peptide: strict or relaxed

AMP-binding (502..918): Hpr

nrpys: Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DIQFSAHVVK
Nearest Stachelhaus code(s):: Hpr DIQFSAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

merA

PKS_AT (582..880): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 190.8
inactive: 94.4
Methoxymalonyl-CoA: 69.9
Methylmalonyl-CoA: 51.4
Propionyl-CoA: 26.6
Isobutyryl-CoA: 25.4
Ethylmalonyl-CoA: 21.5
Acetyl-CoA: 20.3
fatty_acid: 16.1
2-Methylbutyryl-CoA: 13.8
Benzoyl-CoA: 10.0
CHC-CoA: 9.4
trans-1,2-CPDA: 5.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (1591..1876): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 220.0
Methylmalonyl-CoA: 213.8
Methoxymalonyl-CoA: 171.9
2-Methylbutyryl-CoA: 144.0
trans-1,2-CPDA: 139.9
CHC-CoA: 128.0
Propionyl-CoA: 113.7
Malonyl-CoA: 91.7
Isobutyryl-CoA: 79.3
Benzoyl-CoA: 73.8
Acetyl-CoA: 51.7
fatty_acid: 40.7
inactive: 23.2
3-Methylbutyryl-CoA: 19.9

PKS_AT (3044..3329): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.8
Ethylmalonyl-CoA: 209.1
Methoxymalonyl-CoA: 166.8
2-Methylbutyryl-CoA: 145.0
trans-1,2-CPDA: 143.6
Propionyl-CoA: 121.2
CHC-CoA: 118.7
Malonyl-CoA: 87.8
Isobutyryl-CoA: 73.0
Benzoyl-CoA: 67.4
Acetyl-CoA: 53.4
fatty_acid: 41.2
inactive: 22.6
3-Methylbutyryl-CoA: 10.9

PKS_AT (4719..4992): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.4
inactive: 116.1
Methoxymalonyl-CoA: 61.2
Methylmalonyl-CoA: 49.5
Isobutyryl-CoA: 37.6
Propionyl-CoA: 33.5
Ethylmalonyl-CoA: 28.5
Benzoyl-CoA: 28.3
Acetyl-CoA: 18.1
2-Methylbutyryl-CoA: 15.5
fatty_acid: 14.7
CHC-CoA: 11.7
trans-1,2-CPDA: 10.9
3-Methylbutyryl-CoA: 0.0

merB

PKS_AT (558..856): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%; Methylmalonyl-CoA: 79.2%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 186.1
Methylmalonyl-CoA: 179.0
Methoxymalonyl-CoA: 152.5
2-Methylbutyryl-CoA: 119.3
trans-1,2-CPDA: 115.7
Propionyl-CoA: 95.4
CHC-CoA: 89.3
Malonyl-CoA: 81.7
Isobutyryl-CoA: 59.3
fatty_acid: 40.2
Benzoyl-CoA: 33.8
Acetyl-CoA: 29.6
inactive: 20.4
3-Methylbutyryl-CoA: 16.0

PKS_AT (2268..2554): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 214.2
Methylmalonyl-CoA: 208.4
Methoxymalonyl-CoA: 168.0
2-Methylbutyryl-CoA: 148.0
trans-1,2-CPDA: 140.9
CHC-CoA: 114.4
Propionyl-CoA: 113.2
Malonyl-CoA: 88.2
Isobutyryl-CoA: 63.8
Benzoyl-CoA: 55.2
Acetyl-CoA: 40.4
fatty_acid: 40.2
3-Methylbutyryl-CoA: 31.1
inactive: 21.9

PKS_AT (3808..4093): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 211.5
Methylmalonyl-CoA: 210.3
Methoxymalonyl-CoA: 167.2
2-Methylbutyryl-CoA: 148.1
trans-1,2-CPDA: 144.0
CHC-CoA: 121.1
Propionyl-CoA: 120.3
Malonyl-CoA: 89.1
Isobutyryl-CoA: 76.7
Benzoyl-CoA: 70.2
Acetyl-CoA: 56.1
fatty_acid: 41.1
inactive: 25.4
3-Methylbutyryl-CoA: 10.9

PKS_AT (5843..6128): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 214.1
Methylmalonyl-CoA: 209.3
Methoxymalonyl-CoA: 167.0
trans-1,2-CPDA: 142.1
2-Methylbutyryl-CoA: 136.4
CHC-CoA: 124.0
Propionyl-CoA: 117.0
Malonyl-CoA: 89.0
Isobutyryl-CoA: 72.4
Benzoyl-CoA: 62.3
Acetyl-CoA: 46.7
fatty_acid: 33.3
inactive: 21.2
3-Methylbutyryl-CoA: 11.6

merC

PKS_AT (571..844): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.4
inactive: 114.8
Methoxymalonyl-CoA: 58.0
Methylmalonyl-CoA: 49.7
Isobutyryl-CoA: 36.1
Propionyl-CoA: 32.8
Ethylmalonyl-CoA: 30.7
Benzoyl-CoA: 25.9
Acetyl-CoA: 19.4
fatty_acid: 18.9
2-Methylbutyryl-CoA: 14.0
trans-1,2-CPDA: 10.2
CHC-CoA: 8.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (2024..2297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.7
inactive: 113.5
Methoxymalonyl-CoA: 63.3
Methylmalonyl-CoA: 52.5
Isobutyryl-CoA: 38.9
Propionyl-CoA: 35.5
Ethylmalonyl-CoA: 29.4
Benzoyl-CoA: 26.4
Acetyl-CoA: 19.5
2-Methylbutyryl-CoA: 16.2
fatty_acid: 14.7
trans-1,2-CPDA: 12.5
CHC-CoA: 12.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (3477..3764): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 220.4
Methylmalonyl-CoA: 215.2
Methoxymalonyl-CoA: 171.6
2-Methylbutyryl-CoA: 146.9
trans-1,2-CPDA: 145.4
CHC-CoA: 124.6
Propionyl-CoA: 117.3
Malonyl-CoA: 89.4
Isobutyryl-CoA: 72.8
Benzoyl-CoA: 63.4
Acetyl-CoA: 48.4
fatty_acid: 40.7
inactive: 17.5
3-Methylbutyryl-CoA: 15.6

PKS_AT (5004..5277): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.5
inactive: 112.2
Methoxymalonyl-CoA: 60.5
Methylmalonyl-CoA: 52.8
Propionyl-CoA: 36.1
Isobutyryl-CoA: 35.1
Ethylmalonyl-CoA: 32.6
Acetyl-CoA: 23.4
Benzoyl-CoA: 20.5
2-Methylbutyryl-CoA: 18.5
fatty_acid: 15.2
trans-1,2-CPDA: 12.1
CHC-CoA: 11.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (6458..6731): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.9
inactive: 109.3
Methoxymalonyl-CoA: 62.3
Methylmalonyl-CoA: 47.6
Propionyl-CoA: 30.7
Isobutyryl-CoA: 26.2
Benzoyl-CoA: 26.0
Ethylmalonyl-CoA: 25.1
Acetyl-CoA: 20.1
2-Methylbutyryl-CoA: 14.0
fatty_acid: 11.6
CHC-CoA: 10.6
trans-1,2-CPDA: 9.9
3-Methylbutyryl-CoA: 0.0

merD

PKS_AT (158..431): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 217.7
Methylmalonyl-CoA: 210.8
Methoxymalonyl-CoA: 167.1
2-Methylbutyryl-CoA: 151.3
trans-1,2-CPDA: 138.3
CHC-CoA: 118.9
Propionyl-CoA: 114.3
Malonyl-CoA: 85.2
Isobutyryl-CoA: 70.2
Benzoyl-CoA: 64.0
Acetyl-CoA: 51.7
fatty_acid: 37.7
inactive: 20.2
3-Methylbutyryl-CoA: 15.6

PKS_AT (2288..2577): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.5
inactive: 94.1
Methoxymalonyl-CoA: 66.1
Methylmalonyl-CoA: 60.2
Propionyl-CoA: 38.4
Ethylmalonyl-CoA: 29.8
Isobutyryl-CoA: 27.4
Acetyl-CoA: 22.7
CHC-CoA: 16.4
fatty_acid: 13.8
2-Methylbutyryl-CoA: 12.6
trans-1,2-CPDA: 10.8
Benzoyl-CoA: 10.5
3-Methylbutyryl-CoA: 0.0