BGC0001011: meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748
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Location: 1 - 116,831 nt. (total: 116,831 nt).
This entry is originally from NCBI GenBank DQ351275.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001011
Short description meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
DQ351275.1
via
Compounds
  • meridamycin
Species Streptomyces sp. NRRL 30748 [taxonomy]
References
Chemical products information
meridamycin Evidence:
Copy SMILES
C45H75N1O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABC87493.1
 196 - 1083 (-) purine synthase
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    • ABC87494.1
    		 1240 - 2805 (-) purine synthase
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      • ABC87495.1
      		 2802 - 3458 (-) purine synthase
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        • ABC87496.1
        		 3860 - 4702 (+) ion transport protein
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          • ABC87497.1
          		 4765 - 6618 (-) membrane protein
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            • ABC87498.1
            		 6853 - 7737 (-) succinyl-CoA synthetase alpha chain
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              • ABC87499.1
              		 7759 - 8877 (-) succinyl-CoA synthetase beta chain
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                • ABC87500.1
                		 9295 - 10935 (+) beta-1,4-endo glucanase
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                  • ABC87501.1
                  		 11012 - 12352 (-) argininosuccinate synthase
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                    • ABC87502.1
                    		 12652 - 14784 (-) mycodextranase
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                      • ABC87503.1
                      		 14894 - 16492 (-) alpha-1, 4-glucosidase
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                        • ABC87504.1
                        		 16523 - 17398 (-) sugar transporter intracellular portion
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                          • ABC87505.1
                          		 17395 - 18417 (-) sugar transporter intracellular portion
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                            • ABC87506.1
                            		 18356 - 19786 (-) sugar transporter extracellular portion
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                              • ABC87507.1
                              		 19917 - 20915 (-) LacI family transcription regulator
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                                • ABC87508.1
                                • merP
                                		 21568 - 26286 (+) NRPS for pipecolate incorporation
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                                  • ABC87509.1
                                  • merA
                                  		 26259 - 43397 (+) polyketide synthase
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                                    • ABC87510.1
                                    • merB
                                    		 43455 - 64763 (+) polyketide synthase
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                                      • ABC87511.1
                                      • merC
                                      		 64760 - 88666 (+) polyketide synthase
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                                        • ABC87512.1
                                        • merD
                                        		 88050 - 98327 (+) polyketide synthase
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                                          • ABC87513.1
                                          • merE
                                          		 98368 - 99561 (+) cytochrome P450 monooxygenase
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                                            • ABC87514.1
                                            • merF-1
                                            		 99711 - 100367 (-) unknown
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                                              • ABC87515.1
                                              • merF-2
                                              		 100253 - 100789 (-) unknown
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                                                • ABC87516.1
                                                • merG
                                                		 101189 - 102673 (-) drug efflux transporter
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                                                  • ABC87517.1
                                                  • merH
                                                  		 102792 - 103271 (-) drug resistance related regulator
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                                                    • ABC87518.1
                                                    • merI
                                                    		 103353 - 104297 (-) regulatory protein
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                                                      • ABC87519.1
                                                      • merJ
                                                      		 104252 - 105247 (+) membrane protein
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                                                        • ABC87520.1
                                                        • merK
                                                        		 105357 - 106181 (-) unknown
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                                                          • ABC87521.1
                                                          • merL
                                                          		 106294 - 107343 (-) unknown
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                                                            • ABC87522.1
                                                            • merM
                                                            		 107413 - 107820 (-) resistance related regulator
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                                                              • ABC87523.1
                                                              • merN
                                                              		 107905 - 109398 (-) putative drug efflux transporter
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                                                                • ABC87524.1
                                                                • merO
                                                                		 109395 - 110036 (-) drug resistance related regulator
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                                                                  • ABC87525.1
                                                                  • merQ
                                                                  		 110126 - 111172 (-) LysR family regulator
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                                                                    • ABC87526.1
                                                                    • merR
                                                                    		 111037 - 111693 (+) unknown
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                                                                      • ABC87527.1
                                                                      • merS
                                                                      		 111822 - 113201 (+) FAD-dependent monooxygenase
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                                                                        • ABC87528.1
                                                                        • merT
                                                                        		 113251 - 113658 (-) unknown
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                                                                          • ABC87529.1
                                                                          • merU
                                                                          		 113891 - 116341 (-) unknown
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                                                                            • ABC87530.1
                                                                            • merV
                                                                            		 116429 - >116831 (+) methyl transferase
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                                                                              Biosynthesis information
                                                                              Annotation changelog

                                                                              Entry version: 4

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2022-10-07
                                                                              Update chemical activity to schema version 2.11
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                              Entry version: 3

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2022-09-15
                                                                              Updated bioactivity data
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                              Entry version: 2

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2019-10-16
                                                                              Migrated from v1.4
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              2019-10-16
                                                                              Updated compound(s) information (NPAtlas curation)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                              Entry version: 1

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2015-06-12
                                                                              Submitted
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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